Hilal AYDIN, İbrahim BUCAK, Sevda TAŞTAN

Serebral Palsili Çocuklarda B12 Vitamini Düzeyleri Neden Yüksek ?

Amaç: Bu çalışmanın amacı serebral palsi tanısı ile izlenen olguların sağlıklı kontrollere göre vitamin B12 düzeylerinin değerlendirilmesi hedeflenmiştir. Metod: Çalışmaya Adıyaman Üniversitesi Eğitim ve Araştırma Hastanesi çocuk nöroloji polikliniğine başvuran ve serebral palsi tanısı konulan 53 olgu retrospektif olarak dahil edildi. Kontrol grubuna aynı dönemde çocuk sağlığı ve hastalıkları polikliniğine başvuran, sağlıklı çocuk muayenesi girilen ve yaş ve kilo açısından benzer 63 olgu alındı. Hasta dosyalarından demografik veriler, laboratuvar sonuçları [hemoglobin (Hb), hematokrit (Hct), ortalama korpüsküler hacim (MCV), platelet (plt), folat, ferritin, vitamin B12, 25 OH D vitamini], kranial görüntülemeleri ve elektroensefalografi (EEG) bulguları kayıt altına alındı. Bulgular: Çalışma ve kontrol grubunda hemogram parametreleri [Hb (p=0.004), Hct (p=0.000), MCV (p=0.000), plt (p=0.001)], vitamin B12 (p=0.031) ve vitamin D (p=0.002) düzeyleri arasında istatiksel olarak anlamlı düşük saptandı. Sonuç: Çalışmamızda literaturde belirtilen çalışmaların aksine SP’li hastalarda sağlıklı kontrollere göre vitamin B12 düzeyinin daha yüksek olduğu saptanmıştır. Bu durumun altta yatan pato-fizyolojik mekanizması tam olarak bilinmemesini konunun literatürde sınırlı olarak çalışılmasından kaynaklandığı ortadadır.

Anahtar Kelimeler:

Cerebral palsy, vitamin B12, vitamin D, folate

Why Vitamin B12 Levels Are High In Children With Cerebral Palsy ?

Background: The purpose of the present study was therefore to evaluate vitamin B12 levels in cases under follow-up with diagnoses of cerebral palsy (CP) compared to healthy controls. Methods: Fifty-three cases presenting to the Adiyaman University Education and Research Hospital pediatric neurology clinic diagnosed with CP were included retrospectively in this study. Sixty-three cases of similar age and weight presenting to the child health and diseases clinic in the control group. Demographic data, laboratory results [hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), platelet (plt), folate, ferritin, vitamin B12, and vitamin 25 OH D] findings were recorded from the patient files. Results: Complete blood count parameters [Hb (p=0.004), hct (p=0.000), mcv (p=0.000), and plt (p=0.001)], vitamin B12 (p=0.031) and vitamin D levels (p=0.002) were significantly lower in the study group than in the control group. Conclusions: In contrast to previous studies in the literature, vitamin B12 levels were higher in patients with CP than in the healthy controls. The fact that the underlying pathophysiological mechanism is not fully understood clearly derives from the limited investigation of the subject in the literature to date.

Keywords:

Cerebral palsy, vitamin B12, vitamin D, folate,

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