Salim NEŞELİOĞLU, Gültekin PEKCAN, Gamze GÖK, Emine Feyza YURT, Özcan EREL

Lenfomada miyeloperoksidaz/paraoksonaz oranı kullanılarak disfonksiyonel HDL’nin araştırılması

Amaç: Bu çalışmanın amacı, anormal lipid metabolizması, oksidatif stres ve inflamasyon ile karakterize çeşitli lenfoma tiplerinde disfonksiyonel HDL'yi gösteren miyeloperoksidaz / paraoksonaz oranını araştırmaktır.Materyal ve Metot: Çalışmaya 30 lenfoma hastası ve 30 sağlıklı birey alındı. Otomatik analizörde serum myeloperoksidaz, paraoksonaz, arilesteraz, lipid hidroperoksit parametrelerinin ve rutin biyokimya testlerinin düzeyleri ölçüldü. Lenfoma hastalarının tanısı biyopsi materyalinin histolojik incelemesine göre konuldu.Bulgular: Sağlıklı kontrol grubu ile karşılaştırıldığında; albumin, arilesteraz, HDL, tiyol ve Hemoglobin seviyeleri anlamlı derecede düşükken, myeloperoksidaz / paraoksonaz oranı, myeloperoksidaz / arilesteraz oranı ve lipid hidroperoksit seviyeleri, lenfomalı hastalarda anlamlı olarak daha yüksekti. Ayrıca lipid hidroperoksit düzeyi, miyeloperoksidaz / paraoksonaz oranı ve miyeloperoksidaz / paraoksonaz oranı ile anlamlı şekilde ilişkiliydi (sırasıyla r= 0.330, p=0.046; r= 0.588, p< 0.001) Sonuç: Biz disfonksiyonel HDL'nin, lenfoma hastalarında gözlenen inflamatuar süreç, ateroskleroz, oksidatif stres ve bozulmuş lipid metabolizmasında önemli bir faktör olduğunu düşünüyoruz. Gelecekte myeloperoxidase / paraoxonase oranının, disfonksiyonel HDL'ye sebep olan hastalıkları önlemek için bir tedavi kriteri olarak kullanılabileceğine inanıyoruz.

Anahtar Kelimeler:

Arilesteraz, Disfonksiyonel HDL, Lipit hidroperoksit, Myeloperoksidaz/paraoksonaz oranı, Paraoksonaz

Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which indicates dysfunction of high-density lipoprotein in various types of lymphoma characterized by abnormal lipid metabolism, oxidative stress, and inflammation. Methods: Thirty lymphoma patients and 30 healthy subjects were enrolled in this study. Serum myeloperoxidase, paraoxonase, arylesterase, lipid hydroperoxide and routine biochemistry tests levels were measured on an automated analyzer. The diagnosis of lymphoma patients was made according to the histological examination of the biopsy material. Results: Compared with healthy control group; the albumin, arylesterase, high-density lipoprotein, thiol, and Hemoglobin levels were significantly lower while myeloperoxidase / paraoxonase, myeloperoxidase/arylesterase, and lipid hydroperoxide levels were significantly higher, in patients with lymphoma. Also, lipid hydroperoxide level was significantly correlated with myeloperoxidase / paraoxonase and myeloperoxidase / arylesterase (r= 0.330, p=0.046; r= 0.588, p< 0.001, respectively). Conclusions: We think that dysfunctional high-density lipoprotein is an important factor in the inflammatory process, atherosclerosis, oxidative stress, and impaired lipid metabolism that can be observed in patients with lymphoma. We believe that in the future the myeloperoxidase/paraoxonase ratio can be used as a treatment criterion to prevent diseases that cause dysfunctional high-density lipoprotein.

Keywords:

Arylesterase, Dysfunctional HDL, Lipd hydroperoxide, Myeloperoxidase/paraoxonase ratio, Paraoxonase,

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