Türkiye’de Yetişen Bazı Verbascum Türlerinin Sitotoksik Aktivitesi

V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum ve V. splendidum Scrophulariaceae ’un, SK-MEL, KB, BT-549 ve SK-OV-3 kanser hücrelerine karşı sitotoksik aktiviteleri çalışılmıştır. Sonuçlar, bu türlerin metanol ve etil asetat ekstrelerinin sitotoksik aktiviteleri karşılaştırılarak değerlendirilmiştir. V. pterocalycinum var. mutense çiçeklerinin metanol ekstresi, SK-MEL kanser hücresine karşı zayıf sitotoksik aktivite göstermiştir. Bu türün metanol ekstresi üzerinde yapılan biyolojik rehberli fraksiyonlama ile yedi fraksiyon elde edilmiş, ancak, fraksiyonların hiçbirisi sitotoksik aktivite göstermemiştir.

Cytotoxic Activity on Some Verbascum Species Growing in Turkey

V. chionophyllum, V. cilicicum, V. pterocalycinum var. mutense, V. pycnostachycum and V. splendidum Scrophulariaceae were studied for their cytotoxic activities against SK-MEL, KB, BT-549, and SK-OV-3 cell lines. The results were evaluated to compare cytotoxic activity in both their methanol and ethylacetate extracts. The methanol extract of the flowers of V. pterocalycinum var. mutense showed a weak cytotoxic activity against SK-MEL cell line. Through bioassay-guided fractionation on the methanol extract of this species, seven fractions were obtained; however, none of the fractions had cytotoxic activity against cancer cell lines.

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