Azadeh MESRİPOUR, Mahdi AGHAMOHSENİ

2017

Melatonin prevented depressive-like behavior following cyclosporine A or interferon-α administration in mice

Cyclosporine A (CYA) is prescribed to prevent graft rejection after transplantation. Interferon-α (IFN-α), a natural cytokine, is prescribed for some types of malignancies, and hepatitis C virus. But both may cause neurologic complications such as depression following their chronic use. Melatonin is a hormone that helps regulate the circadian rhythm, additionally the melatonin system is connected to depression. The goal was evaluating the antidepressant effect of melatonin following IFN-α, and CYA administration in mice. Male NMRI mice (25-30 g) were used, IFN-α (1600000 IU/kg, sc), CYA (20 mg/kg, ip), melatonin (50 mg/kg, ip), and fluoxetine (20 mg/kg, ip) were administered daily. After evaluating the locomotor activity, depression was assessed by splash test, forced swimming test (FST), and the sucrose preference test. There was no significant difference in the locomotor activity amongest different animal groups. Follow- ing melatonin and IFN-α co-administration immobility time in FST decreased (58.50±19.4s, p<0.01); and during the splash test grooming time increased significantly (114.3±15.3s, p<0.01) compared to the IFN-α alone group, and sucrose preference rose up to 70%. After melatonin and CYA co-administration immobility time during FST decreased (42.33±9.9s, p<0.001); and grooming time increased significantly (103±10.5s, p<0.001) compared to the CYA alone group, sucrose preference also increased up to 93%. The changes induced by melatonin in these experiments were similar to changes made by fluoxetine. Melatonin prevented depression behavior (despair, apathy, and anhedonia) induced by IFN-α, or CYA in mice. The mechanism involved in melatonin antidepressant-like effect warrants further investigations.
Anahtar Kelimeler:

depression, cyclosporine A, interferone-alfa, melatonin, animal model

Melatonin prevented depressive-like behavior following cyclosporine A or interferon-α administration in mice

Cyclosporine A (CYA) is prescribed to prevent graft rejection after transplantation. Interferon-α (IFN-α), a natural cytokine, is prescribed for some types of malignancies, and hepatitis C virus. But both may cause neurologic complications such as depression following their chronic use. Melatonin is a hormone that helps regulate the circadian rhythm, additionally the melatonin system is connected to depression. The goal was evaluating the antidepressant effect of melatonin following IFN-α, and CYA administration in mice. Male NMRI mice (25-30 g) were used, IFN-α (1600000 IU/kg, sc), CYA (20 mg/kg, ip), melatonin (50 mg/kg, ip), and fluoxetine (20 mg/kg, ip) were administered daily. After evaluating the locomotor activity, depression was assessed by splash test, forced swimming test (FST), and the sucrose preference test. There was no significant difference in the locomotor activity amongest different animal groups. Follow- ing melatonin and IFN-α co-administration immobility time in FST decreased (58.50±19.4s, p<0.01); and during the splash test grooming time increased significantly (114.3±15.3s, p<0.01) compared to the IFN-α alone group, and sucrose preference rose up to 70%. After melatonin and CYA co-administration immobility time during FST decreased (42.33±9.9s, p<0.001); and grooming time increased significantly (103±10.5s, p<0.001) compared to the CYA alone group, sucrose preference also increased up to 93%. The changes induced by melatonin in these experiments were similar to changes made by fluoxetine. Melatonin prevented depression behavior (despair, apathy, and anhedonia) induced by IFN-α, or CYA in mice. The mechanism involved in melatonin antidepressant-like effect warrants further investigations.
Keywords:

depression, cyclosporine A, interferon-alfa, melatonin, animal model,

PDF

___

  • 1. Tedesco, D., Haragsim, L. Cyclosporine: A Review. J. Transplant. 2012, 1–7 (2012).
  • 2. Chighizola, C. B., Ong, V. H., Meroni, P. L. The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review. Clin. Rev. Allergy Immunol. 2016 523 52, 401–423 (2016).
  • 3. Mesripour, A., Golbidi, M., Hajhashemi, V. Dextromethorphan improved cyclosporine-induced depression in mice model of despair. Res. Pharm. Sci. 15, 447-453 (2020).
  • 4. Sato, Y., Takayanagi, Y., Onaka, T. & Kobayashi, E. Impact of cyclosporine upon emotional and social behavior in mice. Transplantation 83, 1365–1370 (2007).
  • 5. Anghel, D., Tanasescu, R., Campeanu, A., Lupescu, I., Podda, G., Bajenaru, O. Neurotoxicity of immunosuppressive therapies in organ transplantation. Maedica (Buchar). 8, 170–175 (2013).
  • 6. Mansuy, I. M. Calcineurin in memory and bidirectional plasticity. Biochem. Biophys. Res. Commun. 311, 1195–1208 (2003).
  • 7. Yu, J. J., Zhang, Y., Wang, Y., Wen, Z.Y., Liu, X.H., Qin, J., et al. Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway. Psychopharmacology (Berl). 225, 361–372 (2013).
  • 8. Ignácio, Z. M., Réus, G.Z., Arent, C.O., Abelaira, H.M., Pitcher, M.R., Quevedo, J. New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs. Br. J. Clin. Pharmacol. 82, 1280-1290 (2016).
  • 9. Gong, R., Chang, S. P., Abbassi, N. R. & Tang, S. J. Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J. Biol. Chem. 281, 18802–18815 (2006).
  • 10. Ascierto, P. A., Chiarion-Sileni, V., Muggiano, A., Mandalà, M., Pimpinelli, N., Del Vecchio, M., et al. Interferon alpha for the adjuvant treatment of melanoma: Review of international literature and practical recommendations from an expert panel on the use of interferon. J. Chemother. 26, 193–201 (2014).
  • 11. Sockalingam, S., Links, P. S., Abbey, S. E. Suicide risk in hepatitis C and during interferon-alpha therapy: A review and clinical update. J Viral Hepat. 18, 153–160 (2011).
  • 12. Azimi Fashi, Y., Mesripour, A., Hajhashemi, V. Evaluation of the effect of soybean diet on interferon-α-induced depression in male mice. Avicenna. J. phytomed. 7, 436–443 (2017).
  • 13. Pinto, E. F., Andrade, C. Interferon-Related Depression: A Primer on Mechanisms, Treatment, and Prevention of a Common Clinical Problem. Curr. Neuropharmacol. 14, 743-748 (2016).
  • 14. Le Floc’h, N., Otten, W. & Merlot, E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids vol. 41 1195–1205 (2011).
  • 15. Müller, N., Myint, A. M., Schwarz, M. J. Inflammatory biomarkers and depression. Neurotox. Res. 19, 308–318 (2011).
  • 16. Dubocovich, M. L. Delagrange, P., Krause, D.N., Sugden, D., Cardinali, D.P., Olcese, J. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol. Rev. 62, 343–380 (2010).
  • 17. Hansen, M. V., Danielsen, A. K., Hageman, I., Rosenberg, J., Gögenur, I. The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: A systematic review and meta-analysis. Eur. Neuropsychopharmacol. 24, 1719–1728 (2014).
  • 18. Comai, S., Gobbi, G. Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: A novel target in psychopharmacology. J. Psychiatry. Neurosci. 39, 6–21 (2014).
  • 19. Reiter, R. J., Tan, D., Osuna, C., Gitto, E. Actions of Melatonin in the Reduction of Oxidative Stress. J. Biomed. Sci. 7, 444–458 (2003).
  • 20. Reiter, R. J., Calvo, J. R., Karbownik, M., Qi, W., Tan, D. X. Melatonin and its relation to the immune system and inflammation. Ann. N. Y. Acad. Sci. 917, 376–386 (2000).
  • 21. Wang, S., Tian, Y., Song, L., Lim, G., Tan, Y., You, Z., et al. Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: Role of melatonin and NMDA receptors. Pain. 153, 2448–2457 (2012).
  • 22. Mesripour, A., Shahnooshi, S., Hajhashemi, V. Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. J. Complement. Integr. Med. 17, (2020). https://doi.org/10.1515/jcim-2019-0016.
  • 23. Li, K., Shen, S., Ji, Y.T., Li, X.Y., Zhang, L.S., Wang, X.D. Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling. Neurosci. Bull. 34, 303–311 (2018).
  • 24. Chuang, J., Lin, M.T. Pharmacological effects of melatonin treatment on both locomotor activity and brain serotonin release in rats. J. Pineal Res. 17, 11–16 (1994).
  • 25. Hemsley, K. M., Hopwood, J. J. Development of motor deficits in a murine model of mucopolysaccharidosis type IIIA (MPS-IIIA). Behav. Brain Res. 158, 191–199 (2005).
  • 26. Isingrini, E., Camus, V., Le Guisquet, A.M., Pingaud, M., Devers, S., Belzung, C. Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: A model of fluoxetine resistance in mice. PLoS One 5, e10404 (2010).
  • 27. Mesripour, A., Alhimma, F., Hajhashemi, V. The effect of vitamin B6 on dexamethasone-induced depression in mice model of despair. Nutr. Neurosci. 22, 744–749 (2019).
  • 28. Mesripour, A., Musavie, K., Hajhashemi, V. Creatine and α-lipoic acid improved dexamethasone-induced depressive-like behavioral parameters in mice. Hacettepe Univ. J. Fac. Pharm. 41, 65–73 (2021).
  • 29. Deussing, J. M. Animal models of depression. Drug Discov. Today Dis. Model. 3, 375–383 (2006).
  • 30. Mesripour, A., Almasi, M. Flaxseed prevents interferon-alpha induced depressive behavior in mice: The α-linolenic acid is essential. Res. J. Pharmacogn. 8, 63–71 (2021).
  • 31. Kenis, G., Prickaerts, J., Van Os, J., Koek, G.H., Robaeys, G., Steinbusch, H.W.M., et al. Depressive symptoms following interferon- therapy: Mediated by immune-induced reductions in brain-derived neurotrophic factor? Int. J. Neuropsychopharmacol. 14, 247–253 (2011).
  • 32. Tan, D. Melatonin and Brain. Curr. Neuropharmacol. 8, 161 (2010). 33. Asnis, G. M., De La Garza, R. Interferon-induced depression in chronic hepatitis C: a review of its prevalence, risk factors, biology, and treatment approaches. J. Clin. Gastroenterol. 40, 322–335 (2006).
  • 34. Maddock, C., Baita, A., Orrù, M.G., Sitzia, R., Costa, A., Muntoni, E., et al. Psychopharmacological treatment of depression, anxiety, irritability and insomnia in patients receiving interferon-alpha: a prospective case series and a discussion of biological mechanisms. J. Psychopharmacol. 18, 41–46 (2004).
  • 35. Almeida, A., Guindalini, C., Batista-Neves, S., de Oliveira, I.R., Miranda-Scippa, Â., Quarantini, L.C. Can antidepressants prevent interferon-alpha-induced depression? A review of the literature. Gen. Hosp. Psychiatry 32, 401–405 (2010).
  • 36. Bechstein, W. O. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl. Int. 13, 313–326 (2000).
  • 37. Sato, K., Ogawa, K., Onumata, O., Aso, K., Nakayama, Y., Yoshida, K., et al. Cause of death in renal transplant patients: A comparison between azathioprine and ciclosporin. Surg. Today. 31, 681–687 (2001).
  • 38. Shimmura, H. et al. Analysis of cause of death with a functioning graft: A single-center experience. in Transplantation Proceedings vol. 36 2026–2029 (2004).
  • 39. Illsinger, S., Tanabe, K., Tokumoto, T., Ishida, H., Ishikawa, N., Miyamoto, N., et al. Cyclosporine A: impact on mitochondrial function in endothelial cells. Clin. Transplant. 25, 584–593 (2011).
  • 40. Serkova, N. J. Biochemical Mechanisms of Cyclosporine Neurotoxicity. Mol. Interv. 4, 97–107 (2004).
  • 41. Escames, G., León, J., López, L. C., Acuña-Castroviejo, D. Mechanisms of N-methyl-d-Aspartate Receptor Inhibition by Melatonin In the Rat Striatum. J. Neuroendocrinol. 16, 929–935 (2004).
  • 42. Li, N., Lee, B., Liu, R.J., Banasr, M., Dwyer, J.M., Iwata, M., et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 329, 959–964 (2010).
  • 43. Kim, J., Phongsamran, P., Park, S. Use of antidepressant drugs in transplant recipients. Prog. Transplant. 14, 98–104 (2004).
Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1981
  • Yayıncı: Hacettepe Üniversitesi Eczacılık Fakültesi Dekanlığı
Arşiv
Sayıdaki Diğer Makaleler

Synthesis, Cytotoxic Effect Assessment and Molecular Docking Studies of Disubstituted Thiadiazole Including Oxadiazole as Hybrid Component

Farshid HASSANZADEH, Elham JAFARİ, Sara ZAREI, Hojjat SADEGHI-ALIABADI

Traditional Uses, Pharmacology, Toxicology and Chemical Constituents of an Aphrodisiac Plant, Smilax myosotiflora: A Systematic Review

Rasmaizatul Akma ROSDİ, Mohd Dasuki SUL'AİN, Deny Susanti DARNİS, Wan Rosli WAN ISHAK

Melatonin prevented depressive-like behavior following cyclosporine A or interferon-α administration in mice

Azadeh MESRİPOUR, Mahdi AGHAMOHSENİ

Kemobeyin: Gizemleri ve Açığa Çıkarılmasının Önemi

Meltem TUNCER

Current Novel Nanocarriers in Drug Delivery: A Review

Niharika LAL, Praveen Kumar GAUR, Sameer RASTOGİ, Kanak LATA

Galaxaura rugosa (J. Ellis & Solander) J.V. Lamouroux for Cosmeceutical Application: Antioxidant, Antibacterial, Tyrosinase and Elastase Inhibition Properties

Eldrin ARGUELLES