Esin AKBAY, Handan SEVİM, Özer Aylin GÜRPINAR, Serdar GÜNAYDIN, Mehmet Ali ONUR

Modifiye Edilmiş Miyokardiyal Enfarktüs Rat Modelinden Sonra Hasarlı Kalp Fonksiyonlarının Kemik İliği Mezenşimal Kök Hücreler İle İyileştirilmesi

A kut miyokard infarktüsü ve kalp yetmezliği; tedavideki gelişmelere rağmen günümüzde kardiyovasküler mortalite ve morbiditenin en önemli nedenlerindendir. Bu çalışmada, modifiye edilmiş iskemik kalp modeli oluşturulan Wistar albino sıçanlarda, kemik iliğinden elde edilen mezenşimal kök hücreler ile rejenere olan miyokardiyal alanlar, elektrokardiyografik EKG ve histopatolojik analizler yapılarak gözlenmiştir. Kök hücre uygulama grubunda damar ve hücre sayısında diğer gruplara göre zamana bağlı olarak artış gözlenmiştir. Ayrıca bu grupta EKG verilerinden P dalgası, QRS kompleksi, T dalgası amplitüdleri diğer gruplara göre farklılık göstermezken, T dalgasının süresi ve kalp atım sayısında önemli derecede azalma gözlenmiştir p≤0,001 . Referans grubuna göre kontrol grubunda S-T çökmesinde artış gözlenirken, kök hücre uygulama grubunda azalma gözlenmiştir

Anahtar Kelimeler:

İskemi, kemik iliği mezenşimal kök hücreler, koterizasyon, elektrokardiyogram

Bone Marrow Mesenchymal Stem Cells to Improve Damaged Heart Function after Modified Myocardial Infarction Rat Model

Although nowadays the treatment methods were improved, acute myocardial infarction MI and heart failure are the most important cardiovascular mortality and morbidity causes. In this study, mesenchymal stem cells MSCs collected from the bone marrow was injected into myocardial regeneration areas of the Wistar albino rats with modified ischemic heart model and this areas were investigated by using electrocardiographic ECG data and histopathological analysis. In stem cell implementation group, an increase in the amount of vessels and cells were observed. In this group, the amplitudes of P waves, QRS complex and T waves had no changes, whereas there was a significant reduction on T wave duration and heart beat rate reduced significantly p≤0,001 . S-T depression increased to normal levels was observed in reference and control groups more than in stem cell implementation group.

Keywords:

Ischemia, bone marrow mesenchymal stem cell, cauterization, electrocardiogram,

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