Isı ile İndüklenen Gıda Kirleticisi Akroleine Subkronik Maruziyet: Sütten kesilme ile Postpubertal Dönemdeki Erkek Sıçanlar Üzerindeki Toksikolojik Etkilerin Değerlendirilmesi

Ç ok elektrofilik bir α, β aldehit olan akrolein besinlerde amino asitlerin, yağların ve karbohidratların ısıl işlem görmesi ile oluşmaktadır. Bu çalışmada, akrolein maruziyetinin sütten kesilmeden postpubertal döneme kadar olan süreçteki erkek sıçanların üreme sistemi üzerindeki toksikolojik etkilerini değerlendirmeyi amaçlamaktadır. Bu amaçla, sütten kesilen erkek sıçanlar 90 gün boyunca 0.5, 1 ve 2 mg/kg/gün akroleine ağız yoluyla yolla maruz bırakılmışlardır. Serum testosteron ve lütenleştirici hormon LH düzeyleri ölçülmüş, sperm parametreleri değerlendirilmiştir. Üreme sistemine ait organlar histopatolojik olarak incelenmiştir. Akroleine maruz kalan sıçanların üreme sistemi dokularında çeşitli histopatolojik değişiklikler gözlenmesine rağmen, hormon düzeylerinde ve sperm sayılarında herhangi bir değişiklik gözlenmemiştir

Anahtar Kelimeler:

Akrolein, üreme sistemi, sperm toksisitesi, hormon

Subchronic Exposure of Heat-induced Food Contaminant Acrolein: Evaluation of Toxicological Effects on Male Reproductive Tract from Weaning to Postpuberty

Acrolein is a very electrophilic α, β aldehyde, formed in foods by thermal processing of amino acids, fats and carbohydrates. Due to lack of toxicological information about acrolein exposure, male rats from weaning to postpubertal period was evaluated in terms of reproductive toxicity. Weaning male rats were orally exposed to 0.5, 1 and 2 mg/kg/day acrolein for 90 days. Serum testosterone and lutenizing hormone LH levels were measured and sperm paremeters were evaluated. Reproductive organs were examined histopathologically. Although several histopathological alterations were observed in reproductive organs of rats in acrolein treatment groups, no changes were observed in hormone levels and sperm count.

Keywords:

Acrolein, reproductive system, sperm toxicity, Hormone,

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