Antimikrobiyal Kriyojellerin Sentezi, Karakterizasyonu ve Kromatografik Uygulamaları

P atojenik bakterilerin sebebiyet verdiği hastalıklara karşı antibakteriyel malzemeler son yılllarda olduça önemli bir ilgi merkezi haline gelmiştir. Bu çalışma kapsamında antimikrobiyal poli 2-hidroksietil metakrilat-glisidil metakrilat , pol HEMA-GMA , kriyojeller sentezlenmiş ve yapıya L-Arjinin aminoasidi üzerinden Ag I iyonları immobilize edilmiştir. Yapının karakterizasyonu için; şişme testi, Frouer dönüşümlü infrared FT-IR spektroskopisi, taramalı elektron mikroskobu SEM , yüzey alanı BET , elementel ve ICP-OES analizleri yapılmıştır. L-Arjinin amino asidinden Ag I şelatlayıcı ligand olarak yararlanılmış ve kriyojellerin melittin proteini için adsorpsiyon kapasitesi 173.9 mg protein/g kriyojel olarak tespit edilmiştir

Anahtar Kelimeler:

Antimikrobiyal, kriyojel, L-Arjinin, Ag I .

Synthesis, Characterization and Chromatographic Applications of Antimicrobial Cryogels

Antibacterial materials, in the last years, have become an important center of attention against diseases be- cause of pathogenic bacteria. Within the scope of this study, antimicrobial poly 2-hydroxyethyl methacrylate- glycidyl methacrylate , poly HEMA-GMA , cryogels were synthesized and Ag I ions were immobilized to the structure through the amino acid L-Arginine. For characterization of the structure; swelling test, Fourier transform infrared FT-IR spectroscopy, scanning electron microscopy SEM , surface area BET , elemental analysis and ICP-OES methods were performed. The L-Arginine amino acid was used as an Ag I chelating ligand and the melittin protein adsorption capacity of cryogels was determined as 173.9 mg/g cryogel.

Keywords:

Antimicrobial, cryogel, L-Arginine, Ag I,

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