The Isolation of L-Asparaginase and L-Serine Dehydratase from Bacteria
Kidd 1953 first observed that certain transplanted lymphomas of mice and rats were strongly suppressed by treatment with guinea pig serum, and Broome 1961 provided evidence that L-asparaginase in the serum is the antitumoral factor. The finding by Mashburn and Wriston 1964 that L-asparaginase derived from Escherichia coli has antitumor activity similar to that of guinea pig serum opened up the possibility of large scale production of the enzyme for ultimate clinical trial.
___
- I. Billimoria, M.H.; 1969. Conditions for the productions of L-asparaginase 2 by coliform bacteria. Appl.MiCTObiol. 18: 1025.
- 2. Bollum, F.J., 1966. Filter paper disk techniques for assaying radioactive macromolecules, in Procedures in nucleic acid research. Ed. Cantoni and Davies, Harper and Row Publish. New York and London.
- 3. Broome, J.D., 1961. Evidence that the L-asparaginase activity of guinea pig serum is responsible for its antilymphoma effects. Nature (London) 191: 1114
- 4. Deangeli, L.C.; Pochiari, F.; Tanola, A.; Zurita, V.E.; Ciaranfi, E.; and Perin, A. 1970. Effect of L-asparaginase from Aspergillus terreus on ascites sarcoma in the rat. Nature (London) 225: 549
- 5. Heinemann, B.; Howard, A.J.; and Palocz, H.J., 1970. Influence of dissolvedoxygen levels on production of Lasparaginase and prodigiosin by Serratia marcescens. Appl.Miaobiol. 19:800
- 6. Hill, J.M.; Roberts, J.; Loeb, E.; Khan, A.; Maclellan, A.; and Hill, R.W., 1967. L-Asparaginase therapy for leukemia and other malignant neoplasms, J.Amer. Med.Ass. 202 :882.
- 7. Hill,J.M.; Loeb, E.; Maclellan, A; Khan, A.; Roberts,J.; Schields, W.F.; and Hill, N.O., 1969. Response to highly prufied L-asparaginase during therapy of acute leukemia. Cancer Res. 29:1574.
- 8. Jayaram, H.N.; Ramakrishnan, T.; and Viadyanathan, C.S., 1968. L-asparaginase from Mycobacterium tuberculosis strain H37Rv and H37RA. Arch.Biochem. Biophys. 126:165
- 9. Khan, A.; and Hill, J.M., 1969. Neutralizing precipitin in the serum of a patient treated with. L-asparaginase. J.Lab.Clin.Med. 73 :846
- 10. Kidd,J.G., 1953. Regression o{ transplanted lymphomas induced in vivo by means of normal guinea pig serum. LCourse of transplanted cancers of various kinds in mice and rats given guinea pig serum. J.Exp.Med. 98:565
- 11. Lowry, O.H.; Rosebrough, H.J.; Farr, A.J.; and Randall, R.J., 1951. Protein measurement with the folin phenol reagent. J. Bioi. Chern. 193:265
- 12. Mans, R.].; and Novelli, G.D., 1961. Measurement of the incorporation of radioactive amino acids into protein by a filter paper disk method. Arch.Biochem.Biophys. 94:48
- 13. Mushbum, L.T.; and Wriston,J.C., 1964. Tumor inhibitory effects ofL-asparaginase from E.coli. Arch. Biochem. Biophys. 105:450
- 14. Nelson, G.E.N.; Peterson, R.E.; and Ciegler, A., 1973. Serin dehydratase from bacteria. J. Appl. Bacteriol, 36 :245
- 15. Oettgen, H.F.; Old, L.J.; Boyse, E.A.; Campbell, H.A.; Philips, F.S.; Clarkson, B.D.; Tallal, L.; Leeper, R.D.; Schwartz, M.K.; and Kim,J.H., 1967. Inhibition of leukemias in man by L-asparaginase. Cancer Res. 27 :2619
- 16. Peterson, R.E.; and Ciegler, A., 1969. L-Asparaginase production by Erwinia aroideae, Appi. Microbiol. 18:64 '
- 17. Regan,J.D.; Vodopick, H.; Takeda, S.; Lee, H.; and Faulcon, F.M., 1969. Serin requirement in leukemia and normal blood cells. Science 163: 1452
- 18. Tosa, T.; Sano, R.; Yamato, K.; Nakamura, M.; Ando, K.; and Chibata, 1., 1971. L-Asparaginase from Proteus vulgaris. Appl. Microbial, 22 :387
- 19. Wade, J .E.; Elsworth, R.; Herbert, D.; Keppie, J.; and Sargeant, K., 1968. A new L-asparaginase with anti tumor activity. Lancet 2 :776
- ISSN: 2687-475X
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1972
- Yayıncı: Hacettepe Üniversitesi, Fen Fakültesi
Sayıdaki Diğer Makaleler