Mehmet CAN, Olgun GUVEN, Nurettin SAHİNER

7925

Micro and Nanogels for Biomedical Applications

Micro and nano hydrogels developed from natural and synthetic polymers have garnered great deal of attention in scientific and industrial realms due to their higher surface area, degree of swelling and active material loading capacity, softness and flexibility, as well as their similarity to natural tissues. Particularly, biocompatible, non-toxic, and biodegradable micro/nano vehicles with tailor made design and functionalization facilities their use with excellent feasibility for a variety of biomedical applications such as tissue engineering, bioimaging and drug delivery. However, these platforms require rational design and functionalization strategies to cope with barriers of in vivo environment to pass into clinical use. Firstly, an ideal carrier should be biocompatible, and capable of evasion from immune elimination, specifically target at desired sites and sustainably release the therapeutic cargo in response to microenvironment conditions. Despite the few setbacks in micro/nano vehicle design and several successful formulations translated to clinical use and majority of the carries are yet to achieve complete success for all biological criteria. In this review, design, and functionalization strategies of micro and nanogels have been summarized and the recent progress in biomedical applications of microgels and nanogels have been outlined with a primary focus placed on drug and biomolecule delivery applications.
Keywords:

microgel nanogel, drug delivery, biomedical applications.,

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Hacettepe Journal of Biology and Chemistry-Cover
  • ISSN: 2687-475X
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1972
  • Yayıncı: Hacettepe Üniversitesi, Fen Fakültesi
Arşiv
Sayıdaki Diğer Makaleler

Husnu Yıldırım ERBIL

Begüm YARAR KAPLAN, Ahmet Can KIRLIOĞLU, Esaam JAMİL, Alp YÜRÜM, Naeimeh RAJABALİZADEH, Navid HAGHMORADİ, Bilal İSKANDARANİ, Hamed SALİMKHANİ, Selmiye ALKAN GÜRSEL

Kübra HÜKÜM ÖZKAN, Esma MUTLUTÜRK, Tugba DEMİR ÇALIŞKAN, Tuncer ÇAYKARA

İskender YILGÖR, Emel YILGÖR

Oğuz OKAY

Brabu BALUSAMY, Anitha SENTHAMİZHAN, Tamer UYAR

Mehmet CAN, Olgun GUVEN, Nurettin SAHİNER

Gökhan KOÇAK, Cansel TUNCER, Vural BÜTÜN

Nilay BERELİ, Semra AKGÖNÜLLÜ, Sevgi ASLIYÜCE, Duygu ÇİMEN, İlgim GÖKTÜRK, Deniz TÜRKMEN, Handan YAVUZ, Adil DENİZLİ