Yaygın Damar İçi Pıhtılaşması
Yaygın damar içi pıhtılaşması YDP ; Sepsis, şok, şiddetli dehidratasyon gibi çeşitli olayların seyri sırasında koagülasyon mekanizmasının sistemik olarak aktive edilmesi sonucu damar içinde yaygın fibrin depolanması, hemostatik elemanların parçalanmaı ve tüketimi ile karakterize bir sendromdur 1 . Bu sendrom ‘’Disssemine intravasküler Koagulasyon DİK ’’ olarak da isimlendirilmektedir.
___
- 1. Goodnight SH, Griffin JH. Hereditary Trombophilia. In: Beutler E, Lichtman MA, Coller BS, Seligsohn U (ed.). Willams Hematology. 6th edition. Pensilvellia. McGraw-Hill; 2001. p.1697-707.
- 2. Levi M, ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-92.
- 3. Cate T.H, Somme›jer D. W, Lev› M. Disseminated intravascular caogulation in the new millennium. The Hematology Journal 2002; 3:86-95.
- 4. Sjoukje H. S, Spek C. A, Cate T.H. Disseminated intravascular caogulation. The Hematology Journal 2003; 4:295-302.
- 5. Abildgaard CF, JJ Corrigan, RA Seter, JV Simone, I Schulman. Meningococcemia assosiated with intravascular coagulation. Pediatrics (abst) 1967; 40:78.
- 6. F Fourrier, C Chopin, J Goudemand, S Hendryx, C Caron, A Rime, A Marey. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antitrombin, protein C, and protein S deficiencies. Chest 2000; 101: 816-23.
- 7. Levi M, Cate H, Van Der Poll T, Deventer S. J. Pathogenesis of disseminated intravascular coagulation in sepsis. N Engl J Med 1993; 8: 1132-4.
- 8. Bick R.L, Strauss J.F, Frenkel E.P. Thrombosis and hemorrage in oncology patients. Hematology Oncology Clinics North America 2001; 10: 875-907.
- 9. Levi M, Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341:586-92
- 10. Stormorken H. ‹nterrelationships between the coagulation, the fibrinolytic and the kallikrein and kinin system. Scand. Journal Hematology (abst) 1998; 13:66-9.
- 11. Rodger L.B, B.A. Frenkel, E.P Frenkel. Diseminated intravaskülar coagulat›on:clinical and pathophysiologial mechanisms and manifestations. 15 th international congress on thrombosis. Stockholm. Bildiri Özet Kitab›. S. 209-17, 1998.
- 12. Rock A. Consumption Coagulopathy. In: Behrman R.E, Kliegman M.R, Arvin M.A, Nelson W.E (ed.) Nelson Textbook of Pediatrics. 15th.edition. W.B. Saunders company 1996: p 430-31.
- 13. Karado¤an ‹. Yayg›n damar içi p›ht›laflmas› sendromu. II. Hematoloji ‹lk Basamak Kursu Bildiri Özet Kitab›, Kemer - Antalya s.37-45. 2002.
- 14. E. Atay, M. Akin, E.Yüzkollar, Z. Atay, E. Dursun; Ö. Ceran. Neonatal Purpura Fulminans Associated with Early-Onset Gram- Negative Enterobacter Septicemia: A Case Report. Int.pediat 2000: 162-3.
- 15. Bick RL. Disseminated intravascular coagulation: objective clinical and laboratory diagnosis, treatment, and assessment of therapeutic response. Semin Thromb Hemost(abst) 1996;22:69-88.
- 16. Horan JT, Francis CW. Fibrin degradation products, fibrin monomer and soluble fibrin in disseminated intravascular coagulation. Semin Thromb Hemost 2001; 27: 657-66.
- 17. Wada H, abe Y, Nishioka J, Tomatsu H, Nobori T. Criteria for diagnosing DIC: Rinsho Byori (abst) 2002; 50:273.
- 18. Levi M. Current understanding of disseminated intravascular cagulation. Br. J. Haem 2004; 124: 567-76.
- 19. Levi M, de Jorge E, van der Poll T, Cate H. Novel approaches to the management of disseminated intravascular coagulation. (abst) Crit Care Med 2000; 28:20.
- 20. Monagle P, Michelson AD, Bovill E, Andrew M. Antithrombotic Therapy in Children Chest 2001; 119:344-70.
- 21. Celkan T. Çocukluk ça¤›nda kal›tsal nedenli tromboz. Türk Pediatri Arflivi 2003; 38:131-45.
- 22. Dix D, Marzinotto V, Leaker M, The use of low molecular weight heparin in pediatric patients: a prospective cohort study. J Pediatr 2000:136; 439-45.
- 23. Levi M, de Jorge E, van der Poll T. Therapeutic intervention in disseminated intravascular coagulation: have we made any progress in the last millennium? Blood Rev 2002; 16:29-34.
- 24. Lignell A, Siegbahn A, Stridsberg M, Pauksen K, Gedeborg R, Sjolin J. Low utilization of unactivated protein C in a patient with meningococcal septic shock and disseminated intravascular coagulation. Acta Anaesthesiol Scand 2003; 47:897-900.
- 25. Rawicz M, Sitkowska B, Rudzinska I, Kornacka MK, Bochenski P. Recombinant human activated protein C for severe sepsis in a neonate. Med Sci Monit. (abs) 2002;8:90.