Ahmet ANIK, Gönül ÇATLI, Pınar EDEM, Özlem BAĞ, Ece BÖBER, Ayhan ABACI

Çocukluk Çağında Hiperkalseminin Nadir Bir Nedeni Paratiroid Adenomu: Bir Olgu Sunumu ve Literatürün Gözden Geçirilmesi

Primer hiperparatiroidi çocuklarda çok nadir olarak görülen ve genellikleerişkin dönemde tanı konan bir hastalıktır. Paratiroid bezlerin bir veya dahafazlasında parathormon sentezinde artış sonucu ortaya çıkar. Çocuklarda görülmesıklığı 2-5/100,000 iken erişkinde bu oran 1/1000dir. Tanı anında primerhiperparatiroidili çocukların %73-94ünde hiperkalsemi ile ilgili semptomlargözlenmektedir. Çocukluk çağında gerek semptomların özgül olmaması, gereksede hastalığın erken dönemlerinde hiperkalseminin epizodik olması bu hastalardanefrokalsinozis, nefrolitiyazis, akut pankreatit ve kemik tutulumu gibi hedef organhasarının daha sık gözlenmesine neden olmaktadır. Tüm bu nedenlerden ötürühastalığın erken tanınması ve etkin olarak tedavi edilmesi hedef organ hasarınınengellenmesi açısından oldukça önemlidir. Bu olgu sunumunda hiperkalsemi ileilişkili semtomları olmayan, rastlantısal olarak serum kalsiyum ve parathormondüzeyi yüksek saptanan ve hedef organ hasarı gelişmemiş paratiroid adenomlu11 yaşında bir erkek olgu -nadir görülmesi nedeni ile- literatür bilgisi eşliğindesunulmuştur. (Gün cel Pe di at ri 2014;2:107-11)

A Rare Cause of Hypercalcemia in Childhood; Parathyroid Adenoma: Case Report and Review of the Literature

Hyperparathyroidism is very rare in children (incidence of 2-5 in 100 000) andoccurs predominantly in adults (incidence of 1 in 1000). It is caused by increasedsynthesis of parathormone (PTH) by one or more pathologically effectedparathyroid glands. HPT symptoms are usually non-specific and hypercalcemiamay only be episodic in early period and these characteristics are the causes oflate recognition and diagnosis of pediatric HPT which can culminate with end- organ damage. At the time of the diagnose 73-94% of PHPT cases in youngpatients are recognised as a symptomatic, and end-organ involvement, such asnephrocalcinosis, nephrolithiasis, acute pancreatitis, or bone involvement is notrare which is highly related to the prognosis. Therefore, early recognition andevaluation of symptoms would give a chance to prevent negative outcomes. In thiscase report we describe an incidentally diagnosed parathyroid adenoma in 11 yearold asymptomatic male patient with no end-organ involvement. (The Jo ur nal ofCur rent Pe di at rics 2014;2:107-11)

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