Bülent ÜNAY, Ümit AYDOĞAN, Sebahattin VURUCU, Adem PARLAK, Aytuğ DİKİLİLER, Rıdvan AKIN

Çocukluk çağı kronik günlük baş ağrılarında topiramat tedavisinin etkinliği ve güvenilirliği

Giriş: Bu çalışmada kronik günlük baş ağrısı olan çocuklarda topiramat tedavisinin etkinlik ve güvenilirliği araştırıldı. Gereç ve Yöntem: Bu çalışma kronik günlük baş ağrısı tanısı alan 100 çocuk hasta üzerinde prospektif olarak yapıldı. Hastaların tedavi öncesinde Pediatric Migraine Disability Assesment (PEDMİDAS) skorları ve dereceleri belirlendi. Hastalara 1 mg/kg/gün dozunda (akşam tek doz) topiramat tedavisi başlandı. Tedavinin onuncu gününde ilaç dozu 2 mg/kg/güne yükseltildi. Tedavinin 3. ayında hastaların PEDMİDAS skorları ve dereceleri tekrar değerlendirilerek tedavi öncesi ile karşılaştırılıp, tedavinin etkinliği incelendi. Bulgular: Hastaların tedavi öncesi ve sonrası PEDMİDAS skor ortalamaları sırasıyla 34,60±22,28, 12,77±12,20 olarak bulundu. Bu iki değer arasında istatistiksel olarak anlamlı bir fark vardı (p

The efficacy and reliability of topiramat use in chronic daily headache in childhood

Introduction: In this study, the effectiveness and safety of topiramate treatment in children with chronic daily headache were investigated. Materials and Method: This study was perfomed prospectively among 100 children who were diagnosed with chronic daily headache. Before the treatment, Pediatric Migraine Disability Assesment (PEDMİDAS) scores and grades of the patients were determined. Topiramate was given as 1 mg/kg/day then the dose was increased to 2 mg/kg/day at the tenth day of the treatment. At the third month, PEDMİDAS scores and grades were redetermined and compared with the first one. Results: The PEDMİDAS scores of the patients before and after the treatment were found as 34.60±22.28, 12.77±12.2, respectively. There was a statistical difference between these two values (p

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