Mehmet KARACAN, Haşim OLGUN, Zuhal KESKİN YILDIRIM, Cahit KARAKELLEOĞLU, Naci CEVİZ

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Çocuklarda Kolflisin Zehirlenmesi: 7 Olgu Sunumu

Kolflisin, çeflitli hastalıkların tedavisinde primer olarak kullanılan bir ilaçtır.Kolflisin zehirlenmesi, sık görülmemekle birlikte, çoğul organ tutulumuna nedenolarak hayatı tehdit edici karakterde seyredebilir. Kolflisin zehirlenmesi olanyedi çocuk hasta sunuyoruz. Hastaların yaflları 1 ila 9 arasında idi. Altı hastanınaldıkları kolflisin miktarları 0,16 mg/kg ile 0,39 mg/kg arasındaydı, en sık görülenbulgu kusma ve ishal idi. Bir hastanın almıfl olduğu miktar ise bilinmiyordu. Birhasta kaybedildi, diğer hastalar ise sekelsiz düzeldi. Kolflisin zehirlenmesininciddiyeti, alınan doza ve hastaneye baflvuru zamanına bağlı görünmektedir.Kolflisin zehirlenmesi sonrasında mümkün olan en kısa sürede semptomatiktedavi yapılmalıdır
Anahtar Kelimeler:

Kolflisin, çocuklar, zehirlenme

Colchicine Poisoning in Children: 7 Case Reports

Colchicine is a drug that has been used primarily in several diseases.Colchicine poisoning is an infrequent but potentially life-threatening problemcharacterized by multiorgan involvement. We present seven children withcolchicine poisoning. Their ages ranged between 1 and 9 years. In six children,the amount of colchicine consumed was between 0.16 and 0.39 mg/kg; themost frequent findings were diarrhea and vomiting. In one patient, the ingestedamount was unknown. One of the patients died and all others recovered withoutsequelae. The severity of colchicine poisoning tends to be related to thedosage of ingested drug and the time of admission to hospital. Symptomatictreatment should be started as soon as possible in colchicine poisoning
Keywords:

Colchicine, children, poisoning,

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  • 1. Putterman C, Ben-Chetrit E, Caraco Y, Levy M. Colchicine intoxication: clinical pharmacology, risk factors, features, and management. Semin Arthritis Rheum 1991;21:143-55.
  • 2. Actert G, Scherrman JM, Christen MO. Pharmacokinetic bioavailability of colchicine in healthy male volunteers. Eur J Drug Metabol Pharm 1989;14:317-22.
  • 3. Katar S, Kervancioglu M, Devecioglu C, Nuri Ozbek M. Colchicine poisoning in a very young child. Saudi Med J 2006;27:1598-9.
  • 4. Biçer S, Soysal DD, Ctak A, Uçsel R, Karaböcüo¤lu M, Uzel N.Acute colchicine intoxication in a child: a case report. Pediatr Emerg Care 2007;23:314-7.
  • 5. Kocak Z, Akay H, Gucenmez S, Tufan A, Donderici O. Colchicine intoxication and infection risk:a case report. J Clin Pharm Ther 2008;33:451-2.
  • 6. Wallace SL, Singer JZ. Systemic toxicity associated with intravenous administration of colchicine-guidelines for use. J Rheumatol 1988;15:495-9.
  • 7. Murray SS, Kramlinger KG, McMichan JC, Mohr DN. Acute toxicity after excessive ingestion of colchicine. Mayo Clin Proc 1983;58:528-32.
  • 8. Bismuth C, Baud F, Dally S. Standardized prognosis evaluation in acute toxicology its benefit in colchicine, paraquat and digitalis poisonings. J Toxicol Clin Exp 1986;6:33-8.
  • 9. Sauder P, Kopferschmitt J, Jaeger A, Mantz JM. Haemodynamic studies in eight cases of acute colchicine poisoning. Hum Toxicol 1983;2:169-73.
  • 10. Atafl B, Caksen H, Tuncer O, Kirimi E, Akgün C, Odabafl D. Four children with colchicine poisoning. Hum Exp Toxicol 2004;23:353-6.
  • 11. Eddleston M, Persson H. Acute plant poisoning and antitoxin antibodies. J Toxicol Clin Toxicol 2003;41:309-15.
  • 12. Niel E, Scherrmann JM. Colchicine today. Joint Bone Spine 2006;73:672-8.
  • 13. Donovan JW. Nonsteroidal anti-inflammatory drugs and colchicine. In: Clinical Management of Poisoning and Drug Overdose, 3rd edition. Edited by Haddad LM, Shannon M, Winchester JE. Philadelphia, PA: WB Saunders Company; 1999: 687-99.
  • 14. Milne ST, Meek PD. Fatal colchicine overdose: Report of a case and review of the literature. Am J Emerg Med 1998;16:603-8.
  • 15. Borron SW, Scherrmann JM, Baud FJ. Markedly altered colchicine kinetics in a fatal intoxication: examination of contributing factors. Human Exp Toxiol 1996;15:885-90.
Güncel Pediatri-Cover
  • Başlangıç: 2003
  • Yayıncı: Erkan Mor
Arşiv
Sayıdaki Diğer Makaleler

Çocuklarda Kolflisin Zehirlenmesi: 7 Olgu Sunumu

Mehmet KARACAN, Haşim OLGUN, Zuhal KESKİN YILDIRIM, Cahit KARAKELLEOĞLU, Naci CEVİZ