Kas Gevşetici İlaçCabral®(Feniramidol)’ın Mutajenik Etkisinin Ames Salmonella/Mikrozom Test Yöntemi İle Araştırılması

Günümüzde yaygın olarak kullanılan feniramidol (Cabral®) kas gevşetici etki gösteren analjezik bir ilaçtır. Bu çalışmada amaç feniramidol'ün potansiyel mutajenik etkisinin Ames Salmonella/Mikrozom test sistemi ile saptanmasıdır. Bu amaçla mutajenik etkiyi belirlemek için feniramidol'ün ticari formu olan Cabral®'ın 5 farklı dozu (0.1-1000 µg/plak) Salmonella typhimurium'un TA98 ve TA100 suşları ile muamele edilmiştir. Elde edilen bulgulara göre feniramidol'ün denenen hiçbir dozu TA98 ve TA100 suşlarında mutajenik etki göstermemiştir

Investigation of Mutagenic Effects of Muscle Relaxant Drugs Cabral® (Phenyramidol) by Ames SalmonellaMicrosome Test System

The aim of this study was to determine the possible mutagenic effects of the commercial formulation of phenyramidol (Cabral®) that is extensively used as analgesic muscle relaxant. Ames Salmonella/Microsome test systems were used to determine the mutagenicity of Cabral® using TA98 and TA100 strains of Salmonella typhimurium. Strains were treated with 5 different doses (0.1-1000 μg / plate) of Cabral®. It was shown that phenyramidol was not mutagenic to TA98 and TA100 strains of Salmonella typhimurium

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