Eral İDİL, Alev ÇAM MAHŞER, Mehmet Selman ÖNTAN

8130

Yaşlı Kadınlarda Homosistein Düzeyinin Kırılganlıkla İlişkisi

Amaç: Kırılganlık; düşme, dizabilite, uzun süreli bakım alma ve ölüm riski ile ilişkilendirilen bir geriatrik sendromdur. Bu nedenle kırılganlığın önceden saptanabilmesi ve önlenebilmesi için kırılganlık ile ilişkili olabilecek belirteçlerinin bulunması oldukça önemlidir. Vitamin B12 ve folik asit eksikliği hiperhomosisteinemiye (HHS) neden olmaktadır. HHS; ateroskleroz, tromboemboli, sarkopeni, kemik rezorbsiyonu gibi birçok olumsuz sonuç ile ilişkilendirilmektedir. Tüm bunlar HHS’yi kırılganlığın önemli bir risk faktörü olarak karşımıza çıkarmaktadır. Çalışmadaki amacımız yaşlı kadınlarda homosistein (HS) düzeyi ile kırılganlık ilişkisini ortaya koymaktır. Gereç Yöntem: Retrospektif olarak tasarlanan çalışmamıza 50 yaş üstü, dosya kayıtlarında eksik olmayan 275 kadın hasta dahil edildi. Hastalar HS düzeylerine göre 2 gruba ayrıldı. Hastaların plazma homosistein (HS) değeri için 75. persentile denk gelen 17.2 mmol/L değeri kesme değer olarak alındı. Tüm hastaların kullandıkları ilaç sayısı, sosyodemografik özellikleri, komorbiditeleri, geriatrik sendrom varlığı, laboratuvar sonuçları, ayrıntılı geriatrik değerlendirme (AGD) parametreleri ve kırılganlık durumları kaydedilerek gruplar arası karşılaştırma yapıldı. Bulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 75.35±7.41’di. HS seviyesi düşük olan hastaların %19,0’ında, HHS olanların %37,3’ünde demans tanısı vardı(p
Anahtar Kelimeler:

kırılganlık, homosistein, vitamin B12, folik asit

The Relationship Between Homocysteine Levels and Frailty in Older Women

Aim: Fraility; that is a geriatric syndrome associated with an increased risk of falls, disability, long-term care and death. Therefore, it is very important to find indicators that may be associated with fraility in order to detect and prevent fraility in advance. Deficiencies of vitamin B12 and folic acid cause hyperhomocysteinemia (HHC). HHC is associated with many negative outcomes such as atherosclerosis, thromboembolism, sarcopenia and bone resorption. All of these make HHC an important risk factor for frailty. Our aim in the study is to reveal the relationship between homocysteine (HC) level and frailty in elderly women. Material and Methods: In this retrospective study, we included 275 female patients who were over 50 years of age and whose file records were thorough. The patients were divided into 2 groups according to their HS levels. 17.2 mmol/L, which corresponds to the 75th percentile, was taken as the cut-off value for plasma homocysteine (HC) levels of the patients. For all patients; the number of drugs used, sociodemographic characteristics, comorbidities, presence of geriatric syndrome, laboratory results, comprehensive geriatric assessment (CGA) parameters and frailty status were recorded, and comparisons between groups were made. Findings: The mean age of the patients included in the study was 75.35±7.41 years. Dementia was diagnosed in 19.0% of patients with low HC and 37.3% of patients with HHC (p
Keywords:

fraility, homocysteine, vitamin B12, folic acid,

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Geriatrik Bilimler Dergisi-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2018
  • Yayıncı: Geriatrik Bilimler Derneği
Arşiv
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