Uterin Serviksin Minimal Deviasyon Adenokarsinomu MDA

Minimal deviasyon adenokarsinom MDA servikal adenokarsinomların %1-3 oranında görülen bir varyantıdır.Nadir görülmesi nedeniyle standart tanısal metot ve tedavi protokolü yoktur. Uterin servikste 10-12 cm boyutunda kitlesi olan vakamızda tanı servikal biyopsi ile konamadı.Manyetik rezonans görüntülemede MRI MDA tanısı düşünüldü ve operasyon sonrası tanı kondu. Postoperatif olarak adjuvant kemoradyoterapi KRT uygulandı ve hasta 16 aylık bir süre rekürrens olmadan izlendi

Minimal deviation adenocarcinoma MDA is a variant of cervical adenocarcinomas seen in 1-3%. There is no standard diagnostic methods and treatment protocol because of its rarity.In our case who have a mass in diameter 10-12 centimeters in uterine cervix, the diagnosis could not be established with cervical biopsy. MDA was suspected in magnetic resonance imaging MRI and diagnosis was established after surgery. Adjuvant chemoradiation therapy CRT was administered in postoperative period and the case was followed for 16 months without recurrence

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  • Silverberg SG, Hurg WG. Minimal deviation adenocarcino- ma (“adenoma malignum”) of the cervix: a reappraisal. Am J Obstet Gynecol 1975;121:971-5.
  • Gusserow ALS. Ueber sarcoma des uterus. Arch Gynakol 1870; 1:240e51.
  • McKelvey JL, Goodlin RR. Adenoma malignum of the cer- vix. Cancer 1963;16:549-57.
  • Gliks CB, Young RH, Aguirre P,De Lellis RA, Scully RE. Adenoma malignum (minimal deviation adenocarcino- ma) of the uterine cervix. A clinic pathological and im- munohistochemical analysis of 26 casses. Am J SurgPath 1989;13:717-29.
  • Guiling Li, Wei Jiang, Suiqi Gui, Congjian Xu. Minimal de- viation adenocarcinoma of the uterine cervix. International Journal of Gynecology and Obstetrics 110(2010)89-92.
  • Kyung-Taek Lim, In-Ho Lee, Tae-Jin Kim, Yong-soon Kwon, Jin-Gyu Jeong,Soo-Jin Shin Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. Kashsiung Journal of Medicine Sciences (2012) 28,161-4.
  • Yuko nishii, Takeshi Fuguda, Kenji Imai, Makato Yamauchi, Yasunori Hashuguchi, Tomoyuki Ichimura, Tomoyo Yasui, Toshiyuki Sumi Minimal deviation mucinous adenocar- cinoma of the uterine cervix that proved difficult to diffe- rentiate from endometrial cancer: A case report Oncology letters 8:2481-2, 2014.
  • Yen-Po Chen, Szu-Pei Ho, Wen-Shiung Liou, Chia-Jung Chen Minimal deviation adenocarcinoma of the uterine cervix Taiwanese Journal of Obstetrics and Gynecology 54(2015)447-9.
  • Manjula Jain, Savita Agarwal, Sonal Malhotra: Minimal de- viation adenocarcinoma and its mimickers: A case report with review of literatüre Annals of pathology and labora- tory medicine,Vol 02, No.02,April-June 2015.
  • Dah-Jing Ding, Thang-Yuan Chu, Yung-Hsiang Hsu Tzu Chi Minimal deviation adenocarcinoma of the uterine cer- vix: A case report Medical Journal 28(2016) 79-81.
  • S.B.Park, M.H. Moon, S.R.Hong, M.S.Lee, H.C.Cho, B.H. Han, K.T.Lims Adenoma malignum of the uterine cervix: ultrasonographic findigs in 11 patients Ultrasound Obstet Gynecol 2011;38:716-21.
  • Yamashita Y,Takahashi M, Katabuchi H, Fukumatsu Y, Miyazaki K, Okamura H:Adenoma malignum: MRI appearance mimicking nabothian cysts. Am J Radiol 1994,162(3):649-50.
  • Gotoh T,Kikuchi Y,Takano M, KitaT, OqataS ,aida S,Anzai M; An extremely rare case of adenoma malignum with large cystic tumor which resulted in urinary obstruction. Gyne- col Oncol 2002,84(2)İ:339-43.
  • Jia-Ying Xu, Akiiko Hashi, Tetsuo Kondo, Tsutumo Yumi- namochi, Masatoshi Nara, Keiko Hashi, Shin-Ichi Murata, Ryohei Katoh, Kazuhiko Hoshi Absence of Human Papil- loma Infectio in Minimal Deviation Adenocarcinoma and Lobular Endocervical Glandular Hyperplasia International Journal of Gynecological Pathology 24:296-302.