İskemik İnmenin Etyolojiye Göre Alt Gruplarında Monosit/Hdl-K Oranlarının Karşılaştırılması

Amaç: Monositin yüksek yoğunluklu lipoprotein kolesterole (HDL-K) oranlanmasıyla hesaplanan MHR değerlerinin artışı, son zamanlarda inflamasyon ve oksidatif stres ölçütü olarak değerlendirilen bir parametredir. Kardiyovasküler hastalıklarla ve karotis arter patolojileriyle ilişkilendirildiği veriler mevcuttur. Bu çalışmanın amacı ‘MHR iskemik inmenin etyolojisinde suçlanan bu patolojilerin ayrımında yönlendirici olabilecek bir parametre olabilir mi?’ sorusuna cevap aramaktır. Yöntem: Akut iskemik inme tanısıyla tedavi edilen 200 hastanın kaydı retrospektif olarak incelendi. Hastalardan semptomlarının ilk 24 saati içinde nörolojik muayenesi, nöroradyolojik görüntülemesi (difüzyon mrg ve/veya BBT ile) ve monosit ve HDL-K tetkikleri tamamlanmış, yatışı süresince etyolojiye yönelik tetkikleri sonuçlanan, dışlama kriterleri göz önünde tutularak seçilenler, TOAST sınıflamasına göre gruplandırıldı. Ölçülen monosit değerleri, HDL-K değerleri ve monosit/HDL-K oranlanmasıyla elde edilen MHR değerleri TOAST gruplarına, eşlik eden hastalıklara ve cinsiyete göre istatistiksel olarak incelendi. Bulgular: MHR açısından TOAST grupları arasında istatistiksel olarak anlamlı farklılık gözlenmeksizin erkeklerde ve diyabetik olanlarda MHR değerinde istatistiksel olarak anlamlı yükseklik mevcuttu. Sonuç: MHR, inmenin etyolojiye bağlı alt grupları arasında herhangi bir farklılık göstermediği için bu grupların tahmininde kullanılması uygun bir parametre değildir

Anahtar Kelimeler:

monosit/HDL-K, MHR, iskemik inme, TOAST sınıflaması, monosit/HDL-K, MHR, iskemik inme, TOAST sınıflaması, monocytes/HDL-C, MHR, ischemic stroke, TOAST classification

Comparison of Monocyte/Hdl-C Ratıos in Sub-Groups of Ischemıc Stroke According to Etiology

Abstract Background/Aim:The increase in (MHR) values calculated by the ratio of monocyte to high-density lipoprotein cholesterol (HDL-C) is a parameter that has recently been evaluated as a measure of inflammation and oxidative stress.There are data associated with cardiovascular diseases and carotid artery pathologies.The aim of this study is to seek an answer to the question "Can MHR be a guiding parameter in the differentiation of these pathologies that are blamed in the etiology of ischemic stroke?" Methods:The records of 200 patients with the diagnosis of acute ischemic stroke and whose neurological examination, neuroradiological imaging and monocyte and HDL-C examinations were completed within the first 24 hours after the onset of symptoms were evaluated retrospectively. They were grouped according to the TOAST classification.Measured monocyte values, HDL-C values and MHR values obtained by monocyte/HDL-C ratio were analyzed statistically according to TOAST groups, comorbid diseases and gender. Results:There was a statistically significant increase in MHR in male and in diabetics, without any statistically significant difference between TOAST groups in terms of MHR. Conclusion:MHR is not an appropriate parameter to use in the estimation of these groups, as it does not show any difference between the subgroups of stroke depending on the etiology.

Keywords:

monocytes/HDL-C, MHR, ischemic stroke, TOAST classification,

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