Arzu Şenol

Hepatit B Virus Enfeksiyonu ve Glutatyon

Amaç: Bu çalışmada, hepatit B enfeksiyonlu olgularda, karaciğer enflamasyonunu, hastalık progresyonunu takip etmede tanı için ve karaciğer hasarının ilerleyip, kronik karaciğer hastalığı ve komplikasyonların oluşmasını önlemek için kullanılabilecek antioksidan glutatyonun serum düzeylerine bakıldı. Gereç ve Yöntem: Çalışmaya kronik hepatit B enfeksiyon’lu, ALT düzeyleri normal, HBV DNA Neg-<104 c/ml 55 olgu ile sağlıklı, herhangi bir kronik hastalığı olmayan ve akut hepatit olmayan, 18 yaş üstü 40 kontrol grubu alındı. ELISA (Enzyme-Linked Immunosorbent Assay) yöntemi (R&D Systems, Minneapolis, MN, USA) ile serum GSH düzeyleri belirlendi. Bulgular: Hepatit B virus enfeksiyonlu olguların 29’u kadın, 26’sı erkek (yaş aralığı 43.75±4.33), kontrol grubunun 17’si kadın, 23’ü erkek (yaş aralığı 29.31±1.59) idi. Hepatit B virus enfeksiyonunda glutatyon serum düzeyleri kontrol grubundan düşük olup bu istatiksel açıdan anlamlıydı (p: 0.001). Hepatit B virus enfeksiyonlu olgularda, biyokimyasal parametreler ve glutatyon arasında istatiksel olarak anlamlı bir fark saptanmadı ( p>0.05). Sonuç: Oksidatif stres, karaciğer hasarının gelişimi ve ilerlemesinde önemlidir. Glutatyon, hepatit B enfeksiyonlu olgularda, karaciğer enflamasyonunu, hastalık progresyonunu takip etmede tanı için kullanılabilir. Ayrıca enflamasyonu baskılayarak, kronik karaciğer hastalığı ve komplikasyonların oluşumunu önlemek için kullanılabilir. Daha geniş serili çalışmalar faydalı olabilir.

Anahtar Kelimeler:

Hepatit B virus enfeksiyonu, Glutatyon, Oxidative stress

Glutathione and Chronic Hepatitis B Virus Infection

Abstract Objective: Serum levels of antioxidant glutathione which can be used for diagnosis of liver and liver injury and prevention of chronic liver disease and complications are evaluated. Material and Methods: The study revealed that patients with hepatitis B virus infection had normal ALT levels, HBV DNA Neg- <104 c / ml 55. 40 control group without any disease and no acute hepatitis were included in the study. Serum GSH levels were determined by ELISA (Enzyme-Linked Immunosorbent Assay) method (R&D Systems, Minneapolis, MN, USA). Results: Of the hepatitis B virus infected cases, 29 were female and 26 were male (age range 43.75 ± 4.33), 17 of the control group were female and 23 were male (age range 29.31 ± 1.59). Glutathione serum levels in hepatitis B virus infection were lower than control group and this was statistically significant (p: 0.001). There was no statistically significant difference between biochemical parameters and glutathione in patients with hepatitis B virus infection (p> 0.05). Conculusion: Oxidative stress is important in the development and progression of liver damage Glutathione can be used to diagnose liver inflammation, disease progression. It can also be used to suppress inflammation and prevent the occurrence of chronic liver disease and complications. Broader studies may be useful.

Keywords:

Hepatitis B Virus Infection, Glutathione, Oksidatif stres,

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