Güler KUŞÇU GÜNAY, Tuğba ATOV BAYRAK, Mehmet ÖZDİN

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Lipo(a) ve Paraoksonazın Diabetes Mellitus ile İlişkisi

Bu derlemenin amacı, diabetes mellitus ile Lipoprotein a (lipo a) ve Paraoksonaz-1 (PON1) arasındaki ilişkiyi incelemektir. Bunun için, son on yıldaki orijinal yayınlar taranmıştır. Elde edilen bulgular göstermiştir ki; lipo (a),  birçok kronik ve yüksek mortaliteli hastalıkla ilişkilidir. Araştırmalarda lipo (a) seviyesi yüksek çıkan hastalıklar; miyokard enfarktüsü, kronik böbrek yetmezliği, akciğer kanseri, inme, diabetes mellitus (DM) ve diyabetik nefropati olarak tespit edilmiştir. Öte yandan, karaciğer sirozu olan hastalarda lipoa (a) seviyesinin azalmış olduğu görüldü. Yine bu araştırmaların verilerine göre, DM’ün geniş sistemik tutulumunun lipo (a) seviyesindeki yüksekliğe etkili olduğu görülmüştür. Benzer durum DM ve PON1 düşüklüğü arasında da tespit edilmiştir. İlave olarak, PON1 araştırmalarının, yüksek yoğunluklu lipoproteinin (HDL) ile birlikte yapıldığı görülmüştür. Tüm bu çalışmalarda, PON1 seviyelerinin HDL ile birlikte azaldığı tespit edilmiştir. Sonuç olarak, son yıllarda yapılan pek çok araştırma göstermektedir ki; diabetes mellituslu hastaların PON1 seviyeleri azalırken, lipo (a) seviyeleri yükselmektedir.
Anahtar Kelimeler:

pon1, Lipo(a), diabetes mellitus

The Relationship of Lipo (a) and Paraoxonase with Diabetes Mellitus

The aim of this review is to examine the relationship between diabetes mellitus and lipoprotein a (lipo a) and Paraoxonase-1 (PON1). For this, the original publications of the last decade have been scanned. Findings showed that; lipo (a) is associated with many chronic and high-mortality diseases. In the studies lipo (a) elevated diseases; myocardial infarction, chronic renal failure, lung cancer, stroke, diabetes mellitus (DM) and diabetic nephropathy. On the other hand, the level of lipoa (a) was found to be decreased in patients with liver cirrhosis. According to the data of these studies, extensive systemic involvement of DM was found to be effective on the level of lipo (a). A similar situation was found between DM and PON1. In addition, PON1 studies were performed with high density lipoprotein (HDL). In all of these studies, it was found that PON1 levels decreased with HDL. As a result many studies conducted in recent years show that; PON1 levels of patients with diabetes mellitus decrease, while lipo (a) levels are increased.
Keywords:

PON-1, lipo(a), diabetes mellitus,

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Geleneksel ve Tamamlayıcı Anadolu Tıbbı Dergisi-Cover
  • Başlangıç: 2019
  • Yayıncı: Sakarya Üniversitesi
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Lipo(a) ve Paraoksonazın Diabetes Mellitus ile İlişkisi

Güler KUŞÇU GÜNAY, Tuğba ATOV BAYRAK, Mehmet ÖZDİN