Mesane Küçük Hücreli Karsinomu: Bir Olgu Sunumu

Mesanenin küçük hücreli karsinomları, klinisyenlerin oldukça ender olarak karşılaştığı ve son derece saldırgan davranış gösteren patolojilerdir. Bu çalışmada hematüri ile başvuran, uygulanan transüretral rezeksiyon sonrası doku tanısı mesanenin küçük hücreli kanseri olarak sonuçlanan 63 yaşındaki erkek olgunun histopatolojik ve immunohistokimyasal bulgularının literatür bilgilerimiz eşliğinde sunulması amaçlanmıştır.

Small Cell Carcinoma of the Bladder: A Case Report

Small cell carcinomas of the bladder are rarely encountered by clinicians and are highly aggressive pathologies. In this study, we aimed to present the histopathological andimmunohistochemical findings of a 63-year-old man who presented with hematuria following a transurethral resection, resulting in small cell carcinoma of the bladder.

___

  • 1. Kaya C, Koca O, Keleş O, et al. 6 Yıllık Radikal Sistektomi Deneyimimiz. Marmara Medical Journal 2009;22(1);1-7.
  • 2. Koay EJ, Teh BS, Paulino AC, Butler EB. A Surveillance, Epidemiology, and End Results
  • 3. analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. Cancer 2011;1;117(23):5325-33.
  • 4. Abrahams NA, Moran C, Reyes AO, Siefker-Radtke A, Ayala AG. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology. 2005;46:57-63.
  • 5. Kibar Y, Özgök Y, Göktaş S, Kuzhan O, Tahmaz L, Peker AF. Mesanenin Küçük Hücreli Karsinomu. Türk Üroloji Dergisi 2006;32(1):25-9.
  • 6. Grignon DJ, Ro JY, Ayala AG, et al. Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases. Cancer 1992;15;69:527-36.
  • 7. Cramer SF, Aikawa M, Cebelin M. Neurosecretory granules in small cell invasive carcinoma of the urinary bladder. Cancer 1981;47:724-30.
  • 8. Ekici K, Mayadağlı A, Türk A, et al. Mesanenin Primer Küçük Hücreli Karsinomu: Olgu Sunumu. J Kartal TR 2012;23(3):147-50.
  • 9. Ibrahim NJ, Briggs JC, Corbishley CM: Extrapulmonary oat cell carcinoma. Cancer 1984;54:1645-61.
  • 10. Holmang S, Borghede G, Johansson SL. Primary small cell carcinoma of the bladder: a report of 25 cases. J. Urol. 1995; 153; 1820–12.
  • 11. Lohrisch C, Murray N, Pickles T et al. Small cell carcinoma of the bladder: long term outcome with integrated chemoradiation. Cancer 1999;86:2346–52.
  • 12. Bex A, de Vries R, Pos F, et al. Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. World J Urol 2009;27:101–6.
  • 13. Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS. Small cell carcinoma of the bladder. BJU 2004;94:12-7.
  • 14. Abenoza P, Manivel C, Sibley RK. Adenocarcinoma with neuroendocrine differentiation of the urinary bladder. Clinicopathologic, immunohistochemical, and ultrastructural study. Arch Pathol Lab Med. 1986;110(11):1062-6.
  • 15. Mills SE, Wolfe JT 3rd, Weiss MA, et al. Small cell undifferentiated carcinoma of the urinary bladder. A light-microscopic, immunocytochemical, and ultrastructural study of 12 cases. Am J Surg Pathol. 1987;11(8):606-7.
  • 16. Iczkowski KA, Shanks JH, Allsbrook WC, et al. Small cell carcinoma of urinary bladder is differentiated from urothelial carcinoma by chromogranin expression, absence of CD44 variant 6 expression, a unique pattern of cytokeratin expression, and more intense gamma-enolase expression. Histopathology 1999;35(2):150-6.
  • 17. Jones TD, Kernek KM, Yang XJ, et al. Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum Pathol. 2005;36(7):718-23.
  • 18. Buza N, Cohen PJ, Pei H, Parkash V. Inverse p16 and p63 expression in small cell carcinoma and high-grade urothelial cell carcinoma of the urinary bladder. Int J Surg Pathol. 2010;18(2):94-102.