Abdullah SİVRİKAYA, Zeki TONBUL, Ali Muhtar TİFTİK, Esma MENEVŞE

Is there any association between serum iron and copper levels in hemadialysis patients?

Çalışmanın amacı, hemodiyaliz hastalarında serum demir (Fe), bakır (Cu) ve ferritin düzeylerindeki değişiklikleri tespit etmek ve ferritin düzeyleri ile elementler arasında bir ilişkinin olup olmadığını belirtmekti. Çalışmaya 2-16 yıldır diyalize giren (yaş ortalaması 50.26±16.36) 47 hemodiyaliz hastası (hemodiyaliz grubu) ve 23 sağlıklı kişi (yaş ortalaması 39.52ill.54) (kontrol grubu) dâhil edildi. Hemodiyaliz grubunda kan numuneleri diyaliz öncesi ve sonrası alındı. Veriler, gruplar arasında serum Fe düzeyleri bakımından önemli bir fark bulunmadığını gösterdi. Ancak, diyaliz öncesi Cu düzeyleri ve de diyaliz öncesi ve sonrası ferritin düzeyleri kontrol grubuna göre daha yüksekti (sırasıyla p

Hemodiyaliz hastalarında bakır ve demir düzeyleri arasında herhangi bir ilişki varmıdır?

The aim of the present study was to determine changing in serum iron (Fe), copper (Cu) and ferritin levels in hemodialysis patients and to indicate whether there were any correlations between elements and ferritin levels. The study was carried out on 47 hemodialysis patient with the mean age 50.26±16.36 yr who were dialyzed with a range of 2-16 years. This group called as "Hemodialysis group". Blood samples were taken before (pre-hemodialysis) and after (post-hemodialysis) the hemodialysis session. "Control group" included 23 healthy volunteers with the mean age 39.52Ü1.54 yr. The findings demonstrated that there were no significant differences between the all groups according to data of serum Fe levels. However, serum Cu levels were higher in pre-hemodialysis than the control group (p

PDF

___

1. Van holder R, Cornels R, Dtaisdft; A», Laroeire role of trace elements in wraorac tariofy. Transplant. 2002; 17(2):2-8.
2. Kazi TG, Jalbani N, Kazi N, Jamali MK Arain MB,, Afridi HI, et al. Evaluation of Toxic Metals in Blood and Urine Samples of Chronic Renal Failure Patients, before and after Dialysis. Renal Failure. 2008;30:737-745.
3. Hsu WA, Lee KC, Lin SL, Lee SH, Hsieh SJ, Kan YT. Clinical manifestations of trace metal abnormality in hemodialysis patients: A multicenter collaborative. Dial & Trans. 1997;26:15-16.
4. Zima T, Tesar V, Mestek O, Nemecek K. Trace elements in end-stage renal disease. Blood Purif. 1999; 17:187- 198.
5. Enders HM. Evaluating iron status in hemodialysis patients. Nephrol Nurs J. 2002;29(4):366-370.
6. Kalantar-Zadeh K, McAllister a, Lehn RS, Liu E, Kopple JD. A low serum iron level is a predictor of poor outcome in hemodialysis patients. Am J Kidney Dis. 2004;43(4):671-684.
7. Kirschbaum B. Relationships between the copper and iron systems in hemodialysis patients and variables affecting these systems. Biol Trace Elem Res. 2000;77(l): 13-24.
8. Zima T, Mestek O, Nemecek K, Bartova V. Trace elements in hemodialysis and continuous ambulatory peritoneal dialysis patients. Blood Purif. 1998;16:253-260.
9. Locsey L, Papp L. Study of trace elements ins pafciemts on haemodialysis. Int Urol NephroL 1»15P)2$M5
10. D'Haese PC, Couttenye MM,Lamberts LV, Elseviers MM, Goodman WG, Schrooten I et al Alimium,iron ,cadmium,copper, zinc, chromium,magnesium,stronsium and calcium content in bone of end-stage renal failure patients. Clin Chem. 1999;45:1548-1556.
11. Lin TH, Chen JG, Liaw JM, Juang JG. Trace elements and lipid peroxdation in uremic patients on Hemodialysis. Biol Trace Elem Res. 1996;51:277-283.
12. Krachler M, Scharfetter H, Wirnsbereger GH. Kinetics of the metal cations magnesium, calcium, copper, zinc, stronsium, barium and lead in chronic hemodialysis patients. Clin Nephrol. 2000;54:35-44.
13. Menevşe E, Sivrikaya A, Karagözoğlu E, Tiftik AM, Türk S. Study of elements, antioxidants and lipid peroxidation in hemodialysis patients. Turk J Med Sci. 2006;36(5):279-284.
14. Foret JP. Diagnosing and treating anemia and iron deficiency in hemodialysis patients. Nephrol Nurs X 2002;29(3):292-296.
15. Santoro A, Canova C. Anemia and erythropoietin treatment in chronic kidney diseases. Minerva Urol Nefrol. 2005;57(l):23-31.