BARİATRİK CERRAHİ UYGULAMALARININ MİKROBİYOTA ÜZERİNE ETKİLERİNİN DEĞERLENDİRİLMESİ

Obezitenin tedavisine ve bazı kronik hastalıkların önlenmesine yardımcı olan bariatrik cerrahi uygulaması vücutta çeşitli fizyolojik etkilere neden olmaktadır. Bunlardan birisi mikrobiyota olarak adlandırılan bağırsak florasının içeriğinin değişmesidir. Cerrahi sonrası mikrobiyotanın değerlendirildiği insan ve rat çalışmalarında mikrobiyotanın önemli filumu olan Firmicutes ve Bacteroidetes bakterilerinde bu değişiminin daha çok görüldüğü bilinmektedir. Bağırsakta daha çok kısa zincirli yağ asidi üretimine ve emilimine neden olan Firmicutes filumunda cerrahi sonrası azalma olmaktadır. Cerrahi sonrasında safraya dirençli olan Proteobacteria filumundaki bakterilerde artış olduğu bilinmektedir. Cerrahiye bağlı metabolik değişikliklerin mikrobiyal içeriği etkilediği belirtilmektedir. 

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