The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

Amaç: Düşük dereceli apendiks müsinöz neoplazmlarının (DAMN) invazyona ve psödomiksoma peritoneii'ye (PMxP) neden olma potansiyelleri tartışmalıdır. Bu çalışmada amacımız, bu neoplazmları matriks metalloproteinaz-2 ve -9 invazyon belirteçleri ile incelemektir. Yöntem: Müsinöz adenom, DAMN ve adenokarsinom tanısı almış 28 olgu dahil edildi. Matriks metalloproteinaz-2 ve -9 immünhistokimyasal boyamasları uygulandı ve ekspresyonları skorlandı. Bulgular: Genel bakışta, DAMN'ların çoğunluğu bu belirteçler ile negatifti. Sonuç: DAMN'ler aslında invaziv tabiatta olmayabilir ancak yine de PMxP'ye neden olabilirler. Bu hastalar takip edilmelidir

Matriks Metalloproteinaz-2 ve -9’in Düşük Dereceli Apendiks Müsinöz Neoplazmlarındaki Immünohistokimyasal Ekspresyonu: Bu Neoplazmlar Invaziv Olmayabilir mi?

Objective: Low-grade appendiceal mucinous neoplasms (LAMN) are debated about their potential to cause invasion and pseudomyxoma peritoneii (PMxP). Our aim was to examine these neoplasms by two invasion markers: matrix metalloproteinases- 2 and -9 (MMP). Methods: Twenty-eight cases of mucinous adenomas, LAMNs and adenocarcinomas were included. Immunohistochemistry of MMP-2 and -9 were applied and scored. Results: Overall, the majority of LAMNs were negative by these two markers. Conclusion: LAMNs may not actually have an invasive nature but still they can cause PMxP. These patients should be followed

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