Uğur DİLMEN, Kitapçı Füsun UYSAL, Yasemin ARDIÇOĞLU, E. Esra ÖNAL

Relationship between serum leptin and thyroid hormones in infants with transient tachypnea of the newborn

Amaç: Leptin fonksiyonel çeşitliliği olan bir hormondur. İlk olarak yiyecek alımı ve vücut ağırlığının düzenlenmesi üzerindeki etkileri farkedilmiştir. Ancak daha sonra tiroid hormon sentezi ve akciğer maturasyonu da dahil olmak üzere çok çeşitli biyolojik olaylarda rolü olduğu gösterilmiştir. Bu çalışmada, solunum sıkıntısı olan ve sağlıklı yenidoğanlarda serum leptin düzeyleri ve bunun tiroid hormonları ile olan ilişkisi araştırılmıştır. Yöntem: Hepsi sezaryen ile doğan 21 yenidoğanın geçici takipnesi tanısı alan ve 28 sağlıklı bebek çalışmaya alındı. Serum leptin ve tiroid hormon düzeyleri doğumu izleyen ilk 4 saat içinde ölçüldü. Cinsiyet, doğum ağırlığı, gebelik süresi ve antenatal kortikostedroid kullanımı belirlendi. Serum leptin ve tiroid hormonları gruplar arasında karşılaştırıldı, leptin ile tiroid hormonları arasındaki ilişki araştırıldı. Bulgular: Yenidoğanın geçici takipnesi olan grupta serum leptin düzeyleri (2,79±0,55ng/ml) kontrol grubuna göre (5,53±0,65 ng/ml) belirgin olarak düşüktü (p=0,01). Serum tiroid stimulan hormon (TSH)(p

Yenidoğanın geçici takipnesi olan bebeklerde serum leptin düzeyleri ve tiroid hormonları ilişkisi

Purpose: Leptin is a good example of extreme functional pleiotropy. Originally identified by its effects on food intake and body weight regulation, leptin has subsequently has been shown to play a role in a variety of biological events, including thyroid hormone synthesis and lung maturation. We investigated the serum leptin concentration and its relation to thyroid hormones in respiratory distressed and healthy newborns. Methods: The subjects were 21 infants diagnosed with transient tachypnea of the newborn (TTN) and 28 healthy infants, all delivered by cesarean section. Serum leptin and thyroid hormone levels were measured in the first four hours following delivery. Neonatal gender, birth weight, gestational duration, and antenatal corticosteroid administration were recorded. Intergroup comparisons were made in serum leptin and thyroid hormone levels and the relationship between leptin and thyroid hormone levels was investigated. Results: Serum leptin levels were lower in the TTN group (2.79 ± 0.55 ng/ml) than in the control group (5.53 ± 0.65 ng/ml)(p=0.01). Serum thyroid stimulating hormone (TSH) (p

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