Ayşegül OĞLAKÇI İLHAN, Serhat SİREKBASAN, Filiz YARIMÇAN, Ayşe İSTANBULLU

Investigating the relationship between COVID-19 and total oxidative stress and antioxidant capacity in individuals

Free oxygen radicals are effective in the development and progression of viral infections. The aim of this study was to evaluate the levels of oxidative stress in individuals who have been diagnosed with COVID-19, a viral disease nowadays. The study was carried out between March 2021 and June 2021. Blood samples of 50 patients who applied to Medipol University Faculty of Medicine with suspected COVID-19 infection, whose clinical and molecular diagnoses were corrected and were taken for routine evaluations, were included in this study. In the healthy group, 50 serum samples taken before the COVID-19 pandemic were used. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured, and the data collected were then statistically compared. The TAS level in the COVID-19 group (1.470±0.269) was lower than the healthy group TAS level (1.491±0.286), but it was not statistically significant (p>0.05). The TOS level in COVID-19 group was 13.962 (3.02±36.35) while it was low as 7.925 (1.19±15.03) in the healthy group. The high TOS value in the COVID-19 group was found to be statistically significant compared to the healthy group (p<0.05). Oxidative stress index (OSI) levels, calculated from TOS/TAS, in the COVID-19 group were 9.356 (1.80±26.54) while they were 5.388 (0.98±10.93) in the healthy group. The levels of OSI were found to be significantly higher in the COVID-19 group when compared to the healthy group (p<0.05). The presence of oxidative stress markers in the COVID-19 patients plays an important role in the pathological examination of cell damage. This approach may also pave the way for new therapeutic approaches.

Keywords:

Antioxidant, cell damage, COVID-19, oxidative stress,

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