Sirozlu Hastalarda Renal Kan Akımının Doppler Ultrasonografi ile Değerlendirilmesi

Amaç: Karaciğer sirozlu hastalarda sıklıkla sistemik, splanknik ve renal dolaşımda çeşitli hemodinamik değişiklikler mevcuttur. Bu hemodinamik değişiklikler özellikle ileri evre sirozu olan hastalarda daha belirgin olmaktadır. Biz çalışmamızda sirozlu hastalarda renal kan akımını araştırmayı amaçladık. Materyal ve Metod:Çalışmaya 59 karaciğer sirozlu hasta ve 45 sağlıklı kontrol alındı. Tüm hastaların ve kontrol grubunun her iki böbrek boyutları ve parankim kalınlıkları ölçüldü. Renal vasküler rezistans indeksleri (Rİ) sağ ve sol böbrekten doppler ultrasonografi ile değerlendirildi. Bulgular: Sirotik hastalar ile kontrol grubu karşılaştırıldığında, sırası ile her iki böbrek boyutlarında ve parankim kalınlığında fark yok iken, her iki böbrekten ölçülen renal arter (sağ böbrekten 0,70±0,06 karşılık 0,61±0,03 ve sol böbrekten 0,69±0,06 karşılık 0,61±0,03) ve interlober arter Rİ (sağ böbrekten 0,65±0,06 karşılık 0,57±0,04 ve sol böbrekten 0,66±0,06 karşılık 0,56±0,03) arasında anlamlı fark vardı (p

Doppler Ultrasonographic Evaluation of Renal Blood Flow in Cirrhotic Patients

Objectives: Cirrhotic patients often have various hemodynamic changes in systemic, splanchnic and renal circulation. In our study we aimed to investigate the renal vascular resistance indices of cirrhotic patients by Doppler ultrasonography. Material and Methods: Fifty nine cirrhotic patients and 45 healthy controls were enrolled in this study. Renal vascular resistance indices (RI) of right and left kidney were measured by Doppler ultrasonography. The control group and the cirrhotic patients had similar renal function test results. The cirrhotic patients were classified according to the Child-Pugh scoring. Results: When cirrhotic patients were compared to the control group, although there were no differences in renal size and parenchymal thickness, there were significant differences in renal arterial RI (right kidney; 0,70±0,06 vs 0,61±0,03 and left kidney; 0,69±0,06 vs 0,61±0,03) and interlobar arterial RI (right kidney 0,65±0,06 vs 0,57±0,04 and left kidney 0,66±0,06 vs 0,56±0,03)(p
Keywords:

-,

___

  • Sacerdoti D, Bolognes M, Merkel C, et al. Renal vasoconstriction in cirrhosis evaluated by Duplex Doppler ultrasonography. Hepatology 1993;17:219-224.
  • Platt J, Elis JH, Rubin J.M., et al. Renal duplex Doppler ultrasonography: A noninvasive predictor of kidney dysfunction and 1994;20(2):362-369. in hepatorenal failure liver disease. Hepatology
  • Bateller R, Gines P, Guevara M, et al. Hepatorenal syndrome. Semin Liver Dis 1997; 17 :233-248.
  • Koppel MH, Coburn JW, Mims MM, et al. Transplantation of cadeveric kidneys from patients with hepatorenal syndrome; evidence for the functional nature of renal failure in advanced renal disease. N Engl J Med 1969;280:1367-1371.
  • Iwatsuki S, Popovtzer MM, Corman JL et al. Recovery from hepatorenal syndrome after orthotopic liver transplantation. N Engl J Med 1973;289:1155-1159.
  • Hecker R, Sherlock S. Electrolyte and circulatory changes in terminal liver failure. Lancet 1956; 2:1121-25.
  • Henriksen JH, Hepatorenal disorders: Role of the sympathetic nervous system. Semin Liver Dis 1994;14:35-43.
  • Gaudin C, Braillon A, Poo JL, et al. Regional sympathetic activity of liver disease and hemodynamics in patients with cirrhosis. J Hepatol 1991;13:161-168.
  • Kostreva D, Castener A, Kampine J. Reflex effects of hepatic baroreceptors on renal and cardiac sympathetic nerve activity. Am J Physiol 1980;390-394
  • Solis-Herruzo JA, Duran A, Favela G, et al. Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome. J Hepatol 1987;5:167-173.
  • Schrier RW, Arroyo V, Bernardi M, et al. Peripheral arterial vasodilatation hypothesis: A proposal for the initiaiton of renal sodium and water retantion in cirrhosis. Hepatology 1988;8:1151- 1157.
  • 12.Fitz JG. Approach to the patient with suspected liver disease. In: Friedman SL, McQuaid KR, Grendell JH (eds). Current diagnosis and treatment in gastroenterology. 2 nd ed. 2003:521- 535.
  • 13.Platt JF, Marn CS, Baligna PK. et al. Renal dysfunction in hepatic disease: Early identification with renal duplex Doppler US in patients who undergo liver transplantation. Radiology 1992; 183:801-806.
  • Abdallah AF, Bakr AM, El-Haggar M, et al. Renal hemodynamic changes in children with liver cirrhosis. Pediatr Nephrol 1999;13:854-858.
  • Al-Kareemy EA, Sobh MA, Muhammad AM, et al. Renal dysfunction in liver cirrhosis: renal duplex doppler US vs. scintigraphy for early identification. Clin Radiol 1998;53:44-48.
  • Selami Serhatlıoğlu , Özgür Kocaöz, Adem Kırış ve ark. Karaciger Sirozunda Hepatik ve Renal Hemodinamik Degişikliklerin Doppler US ile Degerlendirilmesi. Fırat Tıp Dergisi 2007;12: 28- 33.
  • Maroto A, Gines A, Salo J, et al. Diagnosis of functional kidney failure of cirrhosis with Doppler sonography: prognostic value of resistive index. Hepatology 1994;20: 839-844.
  • Kareemy EA, Sobh MA, Muhammad AM. et al. Renal dysfunction in liver cirrhosis: renal duplex doppler US vs. sintigraphy for early identification. Clin Radiol. 1998; 53:44-48.
  • Platt JF, Rubin JM, Ellis JH. Acute renal failure: possiple role of duplex doppler US in distinction between acute prerenal failure and acute tubular necrosis. Radiology 1991; 179: 419-424.
  • Colli A, Cocciolo M, Riva C. et al. Abnormal renovascular impedance in patients with hepatic cirrhosis: detection with duplex US. Radiology 1994; 20:362-369.
  • H.Çelebi, E.Dönder, H,Çeliker. Renal blood flow dedection with doppler ultrasonography in patients with hepatic cirrhosis. Arch Intern Med. 1997;157:564-566.
  • Pompilli M, Rapaccini GL, De Luca F. et al. Doppler ultrasonographic evaluation of the early changes in renal resistive index in cirrhotic patients undergoing liver transplantation. J Ultrasound Med. 1999;18:497-502.
  • Rivolta R, Maggi A, Cazzaniga M. et al. Reduction of renal cortical blood flow assessed in cirrhotic patients with refractory ascites. Hepatology 1998;28:1235-1240.
  • Kabul Tarihi:16.04.2008