Gülgun YENER, Caner ACAR, Berna ÖZBEK, Emel MATARACI KARA

Development of Innovative Cosmetic Formulations to Help Fungal Treatment and Testing the Efficiency of Formulations

In the fungus of hands and toenails, the thickening of the nail and its yellow color are the first signs of attention. Fungus on the nails of the hands and feet is often caused by Trichophyton rubrum dermatophyte. They have antifungal properties due to the components found in lavender oil, geranium oil and tea tree oil structures. Oral antifungal agents used for treatment of nail fungi have serious side effects especially on liver. Therefore, topical applications have been given importance in recent years. However, in topical applications antifungal agents have difficulties in sending to the target area. For this reason, nanoemulsion technology was preferred in the study. Nanoemulsion formulations of essential oils were prepared using ultrasonication method. Centrifugal and thermal test were applied as preliminary stability to the formulations and the pH value, viscosity, droplet size and polidispersity index of the formulations passing this step were measured and organoleptic controls were performed. Antifungal efficacy and release studies were performed on the formulations F4P3-I (pelargonium), F4P3-L (lavender), F4P3-C (tea tree) and F4P3-K (mixture) which were successful as a result of all the tests. According to the study, it was concluded that F4P3-I, F4P3-L, F4P3-Ç, F4P3-K formulations may help in the treatment of fungi.

Keywords:

lavender oil geranium oil, tea tree oil, nanoemulsion, ultrasonication,

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