DİŞ HEKİMLİĞİNDE DOKU MÜHENDİSLİĞİNİN YERİ

Doku mühendisliği hasarlı doku ve organların yeniden restore edilmesini amaçlayan bir mühendislik dalıdır. Bu mühendislik dalı, hücrelerin doğal veya sentetik yapı iskelelerine spesifik sinyallerle entegre edilmesi üzerine kurulmuştur. Bu kısa derlemede diş hekimliğinde doku mühedisliği stratejiler ve uygulama alanları olarak iki başlık altında incelenmiştir. Doku mühendisliği stratejilerinde doku kondüksiyonu, doku indüksiyonu, kök hücre nakli ve gen terapisi tanımlanmış, doku mühendisliği uygulama alanlarında da oral kavitenin kemik, kıkırdak, dentin, dental pulpa ve tükürük bezi gibi çe­ şitli dokularında yapılan rejeneratif çalışmalar incelenmiştir. Doku mühendisliği stratejileri ile bugün, deri, kıkırdak gibi dokular laboratuvarda işlendikten sonra bazı medikal uygulamalarda kullanılabil¬ mektedir. Oral kavitenin çeşitli dokularında çok geniş uygulama alanları bulunan doku mühendisliği, diş hekimliğinde devrim niteliğinde olsa da kompleks doku defektlerinin tedavisi üzerine daha çok araştırma yapılmasına ihtiyaç vardır.

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  • Tyagi P. Dhindsa MK. Tissue engine­ ering and its implications in dentistry. Indian Results of a phase- 1 trial. Arch Otolaryngol J. Dent. Res, 2009; 20: 222-26. Head Neck Surg, 1998; 124: 1097-104.
  • Nerem R, Sambanis A. Tissue engi­ neering from biology to biological substituı tes. Tissue Eng, 1995; 1: 3-13.
  • Kaigler D, Mooney D. Tissue primary untreated head and neck squamo­ engineering's impact on dentistry. J Dent Educ, 2001; 65: 456-62.
  • Baum BJ, Mooney DJ The impact of tissue engineering on dentistry. J Am Dent Assoc, 2000; 131: 309-18.
  • Ricci JL, Terracio L. Where is den­ tistry in regenerative medicine . Int Dent J, 2011; 61: 2-10.
  • Ikeda E, Tsuji T. Growing bioengi- neered teeth from single cells: potential for dental regeberative medicine. Expert Opin Biol Ther, 2008: 8; 735-44.
  • Scheller EL, Krebsbach PH, Kohn DH. Tissue engineering: state of the art in oral rehabilitation. J Oral Rehabil, 2009: 36; 368-89.
  • Damien CJ, Parsons JR. Bone graft and bone graft substitutes: a review of cur­ rent technology and applications. J Appl Biomater, 1991: 2; 187-208.
  • Goldberg V M , Stevenson S. Natu­ ral history of autografts and allografts. Clin Orthop Relat Res, 1987; 225: 7-16.
  • Blaese RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M , et al. T lymphocytes-directed gene theraphy for Science, 1995; 270: 475-80.
  • Anderson WF. Human gene therapy. Nature, 1998; 392: 25-30.
  • Nabel GJ. Development of optimized
  • Gleich LL, Gluckman JL, Armstrong S, Biddinger PW, Miller M A , Balakrishnan K, et al. Alloantigen gene theraphy for squ- amous cell carcinoma of the head and neck:
  • Wollenberg B, Kastenbauer, Mundl H , Schaumberg J, Mayer A, Andratschke M , et al. Gene theraphy-phase 1 trial for us cell cancer (HNSCC) UICC stage II-IV with a single interumoral injection of hIL-2 plasmids formulated in DOTMA/Chol. Hum Gene Ther, 1999; 10: 141-47.
  • Mjyers JN. The use of biological the- raphy in cancer of the head and neck. Curr Prob Cancer, 1999; 23: 106-34.
  • Shea L D , et al: DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol, 1999; 17: 551-54.
  • Urist MR. Bone: formation by autoı induction. Science, 1965; 150(3698): 893ı 99.
  • Cochran DL, Wozney JM. Biologiı cal mediators for periodontal regeneration. Periodontol 2000, 1999; 19: 40-58.
  • Akgün ÖM, Polat GG, Altun C. Re
  • jeneratif Pulpa Tedavilerinde Doku Mühen­
  • disliği Uygulamaları Ado Klinik Bilimleri
  • Dergisi, 2008; 2: 238-44.
  • Polverini PJ. The pathophsiology of angiogenesis. Crit Rev Biol Med, 1995; 6: 230-47.
  • Heijl L, et al: Enamel matrix deriva­ tive (emdogain) in the treatment of intrabony periodontal defects. J Clin Periodontol, 1997; 24: 705-14.
  • Tamura RN, et al: Coating of titaniı um alloy with soluble laminin-5 promotes cell attachment and hemidesmosome ası sembly in gingival epithelial cells: potential application to dental implants. J Periodontol Res, 1997; 32: 287-94.
  • Sheridan M E , Shea L D , Peters osteoblast transplantation using poly(DL
  • lactic-co-glycolic acid) foams transplanted MC, Mooney DJ. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control Release, 2000; 64: 91-102.
  • Morrison G. Adances in the skin tra­ de. Mech Engg, 1999; 121: 40-43.
  • Mizuno H, et al: Succesful culture ogenesis by transplanted mouse and human
  • marrow stromal fibroblasts. Transplantation, and sustainability in vivo of gene-modified human oral mucosal epithelium . Hum Gene 1997: 63; 1059-69. Ther, 1999; 10: 825-30.
  • Garlic JA,Fenjves ES. Keratinocyte gene transfer and gene therapy. Crit Rev Oral HR et al. A highly porous 3-dimensional Bio Med, 1996; 7: 204-21.
  • Brittber M , et al: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med, 1994; 331: 889-95.
  • Cao Y, et al: Transplantation of polyurethane foams for bone graft substitu
  • des. J Biomed Mater Res, 2003: 67; 813-27. chondrocytes utilizing a polymer cell consı truct to produce tissue engineered cartilage in the shape of a human ear. Plast Reconstr P, Tuan RS. Multilineage differentiation of Surg, 1997; 100: 297-304.
  • Puelacher WC, Money D, Palge KT, Upton J, Vacanti CA. Design of nasosep- tal cartilage replacements synthesized form biodegradable polymers and chondrocytes. Biomaterials, 1994; 15: 774-78.
  • Jin QM, et al: Cementum engineering with three-dimensional polymer scaffolds. J Biomed Mater Res A, 2003; 67: 54-60.
  • K i m BS, Nikolovski J, Bonadio J, Smiley J, Mooney DJ. Engineered smooth muscle tissues. Regulating cell phenotype with the scaffold. Exp Cell Res, 1999; 251: 318-28.
  • Vacanti CA, K i m W, Upton J, Va­ canti MP, Mooney D, Schloo B et al. Tissue engineered growth of bone and cartilage. Transplant Proc, 1993: 25; 1019-21.
  • Ishaug-Riley SL, Crane GM, Gurlek A, Miller MJ, Yasko AW, Yaszemski MJ et al. Ectopic bone formation by marrow stromal into the rat mesentery. J Biomed Mater Res, 1997; 36: 1-8.
  • Krebsbach PH, Kuznetsov SA, Sato- mura K, Emmons RV, Rowe DW, Robey PG. Bone formation in vivo:comparison of oste
  • Laurencin CT, El-Amin SF, Ibim SE, Willoughby D A , Attawia M , Allcock polyphosphazene polymer matri for skeletal tissue regeneration. J. Biomed Mater Res, 1996; 30: 133-38.
  • Gorna K, Gogolewski S. Preparation, degradation and calfication of biodegradable
  • L i WJ, Tuli R Huang X, Laquerriere human mesenchymal stem cells in a three- dimensional nanofibrous scaffold. Biomate­ rials, 2005; 26: 5158-66.
  • Nuttelman CR, Trpodi MC, Anseth Ks. In vitro osteogenic differentiation of human mesenchymal stem cells photoencap- sulated in PEG hydrogels. J Biomed Mater Res, 2004: 68; 773-82.
  • Payne RG, McGonigle JS, Yaszems- ki MJ, Yasko AW, Mikos AG. Development of an injectable, in situ crosslinkable, deg- radable polymeric carrier for osteogenic wers JM, Mikos AG. Hydroxyapatite fiber cell populations. Part 3. Proliferation and differentiation of encapsulated marrow stro­ mal osteoblasts cultured on crosslinking poly(propylene fumarate). Biomaterials, 2002; 23: 4381-87.
  • Marques AP, Cruz H R Coutinho OP, Reis RL. Effect of starch-based biomaterials on the in vitro proliferation and viability of osteoblast-like cells. J Mater Sci Mater Med, 2005; 16: 833-42.
  • Alsberg E, Anderson KW, Albei- ruti A, Franceschi RT, Mooney DJ. Cell- interactive alginate hydrogels for bone tissue engineering. J Dent Res, 2001; 80: 2025-29.
  • Xu WP, Zhang W, Asrican R, Kim HJ, Kaplan DL, Yelick PC. Accurately sha­ ped tooth bud cell-derived mineralized tissue formation on silk scaffolds. Tissue Eng Part A, 2008; 14: 549- 57.
  • Ducheyne P, el-GhannamA, Shapiro I . Effect of bioactive glass templates on os- teoblast proliferation and in vitro synthesis of bone-like tissue. J Cell Biochem, 1994; 56: 162-67.
  • Reilly GC, Radin S, Chen AT, Duc­ heyne P. Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass. Biomaterials, 2007; 28: 4091-97.
  • Ohgushi H, Okumura M , Tamai S, Shors EC, Caplan A I . Marrow cell induı ced osteogenesis in porous hydroxyapatite and tricalcium phosphate: a comparative histomorphometric study of ectopic bone
  • Z. Selin SIRIK, S. ERGAN, F. Gülbahar IŞIK
  • formation. J Biomed Mater Res, 1990; 24: 1563-70.
  • Yoshikawa T, Ohgushi H , Tamai S. Immediate bone forming capability of prefabricated osteogenic hydroxyapatite. J Biomed Mater Res, 1996; 32: 481-92.
  • Thomson RC, Yaszemski MJ, Po­ reinforced poly(alpha-hydroxy ester) foams for bone regeneration. Biomaterials, 1998; 19:1935-43.
  • Kretlow JD, Mikos AG. Review: miı neralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng, 2007; 13: 927-38.
  • Segvich S, Smith HC, Luong L N , Kohn DH. Uniform deposition of protein incorporated mineral layer on threedimensio- nal porous polymer scaffolds. J Biomed Ma­ ter Res B Appl Biomater, 2008; 84: 340-49.
  • Ciocca L, De Crescenzio F, Fantini M , Scotti R. CAD/CAM and rapid prototy­ ped scaffold construction for bone regenera­ tive medicine and surgical transfer of virtual planning: a pilot study. Comput Med Imaı ging Graph 2009: 33; 58-62.
  • Fortier LA. Stemcells: classification, controversies and clinical applications. Vet Surg, 2005; 34: 415-23.
  • Wang Y, Preston B, Guan G. To­ oth bioengineering leads the next genera­ tion of dentistry. Int J Paediatr Dent 2012 doi:10.1111/j.1365-263x.2011.01206x (inpı ress)
  • Ikada Y. Challenges in tissue enginee­ ring. Journal of the Royal Society Interface, 2006; 22: 589-601.
  • Heng BC ve Cao T, Stanton lW, Rob- son P, Olsen B. Strategies for directing the differentiation of stem cells into the osteo- genic lineage in vitro. J Bone Miner Res, 2004; 19: 1379-94.
  • Yen AH, Sharpe PT. Stem cells and tooth tissue engineering. Cell Tissue Res, 2008; 331: 359-72.
  • Gronthos S, Brahim J, L i W, Fisher LW, Cherman N , Boyde A et al. Stem cell properties of human dental pulp stem cells. J Dent Res, 2002; 81: 531-35.
  • Seo BM, Miura M , Gronthos S, Bar- told PM, Batouli S, Brahim J et al. Invesı tigation of multipotent postnatal stem cells from human periodontal ligament. Lancet, 2004; 364: 149-55.
  • Sauerbier S, Stricker A, Kuschnierz J, Bühler F, Oshima T, Xavier SP, Schmel­ zeisen R, Gutwald R. In vivo comparison of hard tissue regeneration with human me- senchymal stemcells processed with either the FICOLL method or the BMAC method. Tissue Eng Patr C Methods 2010: 16; 215ı 23.
  • Morsczeck C, et al: Somatic stem hashi M , Hata K, Nagasaka T. Autogenous
  • injectable bone for regeneration with me- cells for regenerative dentistry. Clin Oral Investig, 2008; 12: 113-18.
  • Bluteau G, Luder HU, De Bari C, Mitsiadis TA. Stem cells for tooth engineeı ring. Eur Cell Mater, 2008; 16: 1-9.
  • Nakahara T. Potential feasibility of detal stem cells fo regenerative therapies: cell-calcium phosphate constructs for bone stem cell transplantation and whole tooth engineering. J Dent Res, 2010; 89: 1482-88. engineering Odontology, 2011; 99: 105-11.
  • Yao S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental follicle. J Dent Res, 2008; 87: 767-71.
  • Chen F, et al: Anchoring dental imp­ lant in tissue engineered bone using comı posite scaffold: a preliminary study in nude mouse model. J Oral and Maxillofac Surg, preliminary report. J Craniomaxillofac Surg, 2006; 63: 586-91. 2003; 31: 34-39.
  • Dunn CA, et al: BMP gene delivery for alveolar bone engineering at dental imp­ lant defects. Mol Ther, 2005; 11: 294-99.
  • Hibi H, Yamada Y, Kagami H, Ueda after sinus augmentation with engineered M . Distraction osteogenesis assisted by tisı sue engineering in an irradiated mandible: a case report. Int J Oral Maillofac Implants, 2006; 1: 141-47.
  • Ito K , et al; Simultaneous implant placement and bone regeneration around dental implants using tissue- engineered bo­ ne with fibrin glue, mesenchymal stem cells and platelet-rich plasma. Clin Oral Implants Res, 2006; 17: 579-86.
  • Yamada Y, et al: Tissue-engineered injectable bone regeneration for osseointeg- rated dental implants. Clin Oral Implants Res, 2004; 15: 589-97.
  • Yamada Y, Ueda M Hibi H, Naga- saka T. Translational research for injectable tissue engineered bone regeneration using mesenchymal stemcells and platelet-rich plasma from basic research to clinical case study . Cell Transplant, 2004: 13: 343-55.
  • Yamada Y, Ueda M , Naiki T, Taka- senchymal stem cells and platelet rich plası ma: tissue engineered bone regeneration. Tissue engineered bone egeneration. Tissue Eng, 2004: 10: 955-64.
  • Xu H H , Zhao L , Weir M D . Stem
  • Marei M K , et al: Preservation and regeneration of alveolar bone by tissue-enı gineered implants. Tissue Eng, 2005; 11: 751-67.
  • Schmelzeisen R, et al: Making Bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation - a
  • Zizelmann C, Schoen R, Metzger MC, Schmelzeisen R, Schramm A, Dott B, Bormann K H , Gelrich NC. Bone formation bone. Clin Oral Impl Res, 2007; 18: 69-73.
  • Duraine G, Hu J, Athanasoiu K. Bio- engineering in the oral cavity: insights from articular cartilage tissue engineering. Int J Oral Maxillofac Implants. 2011; 26: 11-24.
  • Jin X. Recent progress of researches in cartilage tissue engineering. Zhongguo equivalents: characterization in athymic mi­ Xiu Fu Chong Jian Wai Ke Za Zhi, 2011; 25: 187-92.
  • Murray PE, et al: Regenerative en- dodontics: a review of current status and a call for action. J Endod, 2007; 33: 377-87.
  • Hacking SA, Khademhosseini A. Applications of microscale technologies for regenerative dentistry. J Dent Res, 2009; 88: 409-21.
  • Prescott RS, et al: In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod, 2008; 34: 421-26.
  • Yıldırım S, Alaçam A, Sarıtaş ZK, Oygür T. Transforming Growth Factor B1'in pulpa tedavilerinde kullanılabilirliğinin his- topatolojik olarak araştırılması. GÜ Diş Hek Fak Derg, 2001; 18: 123-32.
  • Xie HT, Wang GJ, Sun JG, Tucker I , Zhao XC, Xie Y Y et al. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. J Chromatogr, 2005; 818: 167-73.
  • Kagami H, Wang S, Hai B. Restoring the function of salivary glands. Oral Dis, 2008; 14: 15-24.
  • Sugito T, Kagami H, Hata H. Trans­ plantation of cultured salivary gland cells into an atrophic saivary gland. Cell Transı plant, 2004; 13: 691-99.
  • Delporte C, O'Connell BC, He X. Increased fluid secretaion after adenoviral- mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A 1997; 94: 3268-73.
  • Pena I , Junquera L M . Meana A, Garcia E, Aguilar C, Fresno F M . In vivo behavior of complete human oral mucosa
  • Ueda M , Tohnai I , Nakai H. Tissue engineering research in oral implant surgery. Artif Organs, 2001; 25: 164-71.
  • Garcia-Godoy F, Murray P. Regene­ rative Dentistry: Translating Advancements in Basic Science Research to the Dental Prac­ tice. J Tenn Dent Assoc, 2010; 90: 12-8.
European Oral Research-Cover
  • ISSN: 2630-6158
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1967
  • Yayıncı: İstanbul Üniversitesi
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