Relationship between Thyroid Volume and Baseline Vitamin D Levels in New-Onset Graves Disease

Relationship between Thyroid Volume and Baseline Vitamin D Levels in New-Onset Graves Disease

Objective: Serum vitamin D is shown to be decreased and associated with higher thyroid volumes in Graves disease (GD). We aimed toinvestigate the relationship between thyroid volume and baseline serum vitamin D status in newly diagnosed GD patients.Methods: This was a single-center cross-sectional study with a total of 61 new-onset GD patients (n=61, F: 40, M: 21) who weredivided into two groups, according to baseline serum vitamin D levels, as Group-1 (vitamin D

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  • Bizzaro G, Shoenfeld Y. Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. Immunol Res 2015; 61: 46-52.
  • Vondra K, Starka L, Hampl R. Vitamin D and Thyroid Diseases. Physiol Res 2015; 64: 95-100.
  • Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Danko K et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol 2011; 8: 243-7.
  • Kurylowicz A, Ramos-Lopez E, Bednarczuk T, Badenhoop K. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves’ disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol 2006; 114: 329-35.
  • Abd el Gawad SS, Samee Er Abdul, Metwali AA, Abd el Gawad MS. Vitamin D receptor gene polymorphism and its association with 1,25-dihydroxyvitamin D in patients with Graves disease in an Egyptian population: a pilot study. Endocr Pract 2012; 18: 132-9.
  • Ramos-Lopez E, Kurylowicz A, Bednarczuk T, Paunkovic J, Seidl C, Badenhoop K. Vitamin D receptor polymorphisms are associated with Graves’ disease in German and Polish but not in Serbian patients. Thyroid 2015; 15: 1125-30.
  • Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine 2012; 42: 739-41.
  • Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, et al. Serum vitamin D levels are decreased in patients without remission of Graves’ disease. Endocrine 2013; 43: 230-2.
  • Hollick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
  • Shabana W, Peeters E, De Maeseneer M. Measuring thyroid gland volume: should we change the correction factor? AJR Am J Roentgenol 2006; 186: 234-6.
  • Yin K, Agrawal DK. Vitamin D and inflammatory diseases. J Inflamm Res 2014; 7: 69-87.
  • Bouillon R. Vitamin D: from photosynthesis, metabolism and action to clinical applications. In: Endocrinology, Jameson JL, De Groot LJ, Saunders Elsevier, Philadelphia 2010.
  • Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010; 10: 482-96.
  • Li YB, Xue XH, Liu SW, Xi GX, Zhao LX, Zhang XL. Clinical research of serum vitamin D in early Graves disease. Chin Rem Clin 2014; 14: 242-3.
  • Miao W, Ma J, Guo R, Wang YJ, Wang G, Guan HX. Research about the correlation between Serum 25(OH)D with Graves’ disease. Chin. J Pract Internal Med 2013; 33: 394-95.
  • Fournier C, Gepner P, Sadouk M. In vivo beneficial effects of cyclosporin A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54: 53-63.
  • Choi YM, Kim WG, Kim TY. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 2014; 24: 655-61.
  • Zhang H, Liang L, Xie Z. Low vitamin D status is associated with increased titers of thyroid stimulating hormone receptor antibodies in Graves disease. Endocr Pract 2015; 21: 258-63.
  • Feng M, Li H, Chen SF. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013; 43: 318-26.
  • Xu MY, Cao B, Yin J, Wang DF, Chen KL, Lu QB. Vitamin D and Graves’ Disease: A Meta-Analysis Update.Nutrients 2015; 7: 3813-27.
  • Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol 2014; 170: 241-52.
  • Inoue N, Watanabe M, Ishido N. The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases. Clin Exp Immunol 2014; 178: 262-9.
  • Yazici D, Yavuz D, Tarcin O. Vitamin D receptor gene ApaI, TaqI, FokI and BsmI polymorphisms in a group of Turkish patients with Hashimoto’s thyroiditis. Minerva Endocrinol 2013; 38: 195-201.
  • Pantazi H, Papapetrou PD. Changes in parameters of bone and mineral metabolism during therapy for hyperthyroidism. J Clin Endocrinol Metab 2000; 83: 1099-106.
European Journal of Therapeutics-Cover
  • ISSN: 2564-7784
  • Başlangıç: 1990
  • Yayıncı: Fatma Taşçı