Ebru UNCU, Yasemin ZER, Mustafa PEHLİVAN, Tekin KARSLIGİL, Haydaroğlu Handan ŞAHİN, Vahap OKAN

Nadir rastlanan bir bakteriyemi etkeni: Leuconostoc spp

İmmünsüpresif tedavi alan akut myelositik lösemili (AML) 53 yaşındaki kadın hastada tekrarlayan bakteriyemi atakları sonrasında, kan kültürü örneğinden Leuconostoc spp. izole edildi. Doğada yaygın olarak bulunan Leuconostoc spp. vankomisine doğal dirençli Gram pozitif bir bakteridir. Enfeksiyonlarda nadiren hastalık etkeni olarak soyutlansa da özellikle immünsüprese hastalarda çeşitli sistemik enfeksiyonlara neden olmaktadır. Bu olgu laboratuvarımızda ilk kez bakteriyemi etkeni olarak Leuconostoc spp izole edilmesinden dolayı sunulmuştur.

Anahtar Kelimeler:

İmmünosüpresyon; kan kültürü; Leuconostoc spp.; vankomisin direnci.

A rare cause of agents of bacteremia: Leuconostoc spp.

After repeated bacteremia attacks in 53-year-old female patient with acute myeloid leukemia (AML) under immunosuppressive treatment, Leuconostoc spp. is isolated from blood culture. Leuconostoc spp. is a vancomycin natural resistant Gram-positive bacterium common in nature. Although it is rarely isolated as an agent in infections, it causes various systemic infections especially in immunosuppressive patients. This case is presented for the first isolation of Leuconostoc spp., as an agent of bacteremia in our laboratory.

Keywords:

Immunosuppression; blood culture; Leuconostoc spp.; vancomycin resistance.,

PDF

___

1.Arias AC, Murray BE. Enterococcus species, Streptococcus bovis group, and Leuconostoc species. In: Mandell GL, Bennett JE, Dolin R, ed. Principles and practice of Infectious Diseases 7th ed. Philadelphia. Churchill Livingstone, 2010; 2643-2653
2.Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Winn WC Jr. The gram positive cocci. Part II; Streptococci, enterococci and the Streptococcus like bacteria. In: Koneman's Color Atlas and Textbo¬ok of Diagnostic Microbiology, 5th ed. Lippincott, Philadelphia, 1997;577-650
3.Handweger S, Horowitz H, Coburn Kenneth, Kolokathis A, Wormser PG. Infection due to Leuconostoc species; Six cases and Review. Clin Infect Dis 1990;12: 602-10
4.Ishiyama K, Yamazaki H, Senda Y, Yamauchi H, Nakao S
Leuconostoc bacteremia in tree patients with malignancies. J Infect Chemother 2011;17:412-18
5.Vagiakou-Voudrıs E. Mylona-Petropoulou D, Kalogeropoulou E, Chantzis A, Chini S, Tsiodra P, Malamou-Lada E. Multiple liver abscesses associated with bacteremia due to Leuconostoc lactis. Scand J Infect Dis 2002;34:766-7
6.Jimenez-Mejias ME, Becerril B. Gomez CT, del Nozal M, Palamino-Nicas J. Bacteremia caused by Leuconostoc cremoris in a patient with severe burn injuries. Eur J Clin Microbiol Infect Dis 1997;16:533-5
7.Coovadia YM, Solwa Z, van den Ende J. Meningitis caused by vancomycin-resistant Leuconostocs spp. J Clin Microbiol 1987;25:1784-5
8.Aygun H, Bozkurt GY, Memikoglu O, Cokca F. Case report: two Leuconostoc bacteremia cases. Mikrobiyol Bul 2005;39:225-8
9.Gillespie RS, Symons JM, McDonald RA. Peritonitis due to Leuconostoc species in a child receiving peritone¬al dialysis
Pediatr Nephrol 2002;17:966-8
10.Patel T, Molloy A, Smith R, Balakrishnan I. Successful of Leuconostoc bacteremia in a neutropenic patient with tigecycline. Infectious Disease Report 2012;4:124-5
11.Bernaldo de Quiros JC, Munoz P, Cercenado E, Hernandez Samplayo T, et al. Leuconostoc species as a cause of bacteremia: two ca¬se reports and a literature review. Eur J Clin Microbiol Infect Dis 1991;10:505-9
12.Handweger S, Horowitz H, Coburn Kenneth, Kolokathis A, Wormser PG. Infection due to Leuconostoc species; Six cases and Review. Clin Infect Dis 1990;12:602-10
13.Florescu D, Hill L, Sudan D, Iween PC. Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review. Pediatr Infect Dis J 2008; 27:1013-9
14.Green M, Wadowsky RM, Barbadora K. Recovery of vancomycin-resistant gram-positive cocci from child¬ren. J Clin Microbiol 1990;28:484-8
15.Handwerger S, Pucci MJ, Volk KJ, Liu J, Lee MS
Vancomycın-resistant Leuconostoc mesenteroides and Lactobacillus casei synthesize cytoplasmic peptidoglycan precursors that terminate in lactate. J Bacteriol 1994;176:260-4