Murat SEZER, Mehmet YAMAN, Serdar ORUÇ, Fatma FİDAN, Mehmet ÜNLÜ

VISUAL EVOKED POTENTIAL CHANGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Anahtar Kelimeler:

-

VISUAL EVOKED POTENTIAL CHANGES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Aim: The normal visual evoked potential (VEP) reflects the functional integrity of the visual pathways from retinal to occipital striate area. Visual reseptors are sensitive to hypoxemia. Chronic obstructive pulmonary disease (COPD) is a progressive disease, in which hypoxemia occurs due to ventilation-perfusion imbalance. We aimed to evaluate the effects of COPD on VEPs. Methods: Thirty eight COPD patients and 17 healthy control subjects were accepted to the study. Pulmonary function tests were performed to all the participants. VEP of all participants were recorded. Results: P1 (P100) values of both right and left eyes (p=0.008 and p=0.010, respectively) and N2 value of right eye (p=0.030) were significantly higher in COPD patients than the control group. As there was just 1 female COPD patient, the measurements were re-evaluated for just male subjects. P1 values of both right and left eyes were significantly higher in male COPD patients than male control subjects (p=0.031 and p=0.023, respectively). Conclusion: VEPs, particularly P1 value, alters in COPD patients. This change in VEPs was thought to be due to hypoxemia caused by ventilation-perfusion imbalance in COPD

Keywords:

COPD, VEP hypoxemia,

PDF

___

Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease NHLBI/ WHO Workshop Report. Global initiative for chronic obstructive pulmonary disease. National Institutes of Health, 2001:12-25
Rodriguez-Roisin R, MacNee W. Pathophysiology of chronic obstructive pulmonary disease. Eur Respir Mono 1998;3:107–26
McLean A, Warren PM, Gillooly M, MacNee W, Lamb D. Microscopic and macroscopic measurements of emphysema: relation to carbon monoxide gas transfer. Thorax 1992;47:144–9
Fowler B, Banner J, Pogue J. The slowing of visual processing by hypoxia. Ergonomics 1993;36:727-35
Deecke L, Goode RC, Whitehead G, et al. Hearing under respiratory stress: latency changes of the human auditory evoked response during hyperventilation, hypoxia, asphyxia and hypercapnia. Aerosp Med 1973;44:1106-11
McFarland RA. Experimental evidence of the relationship between aging and oxygen want: in search of aging. Ergonomics 1963;6:338-66
McFarland RA. The effects of altitude on pilot performance. In Hannisdahi B, Sen-Jacobsen G, eds. Aviation and Space Medicine. Oslo: Universities Forloget; 1969:96-8
Tandon OP. Average evoked potentials- Clinical applications of short latency responses. Indian J Physiol Pharmacol 1989;42:172-88
Tandor OP, Ram D. Visual evoked potentials in primary hypertension. Indian J Physiol Pharmacol 1997;41: 154-8
Durmaz S, Karagol U, Deda G, Onal MZ. Brainstem auditory and visual evoked potentials in children with protein-energy malnutrition. Pediatr Int 1999;41:615-9
Meinck HM, Adler L, Rader K, Conrad B. Delayed visual evoked potentials in chronic alcoholism. J Neurol 1986;233: 161-3
Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Pulmonary Disease: NHLBI/WHO Workshop Report. Updated 2003:1-112
Seki K, Nakasato N, Fujita S, et al. Neuromagnetic evidence that the P100 component of the pattern reversal visual evoked responses originates in the bottom of the calcarine fissure. Electroencephalogr Clin Neurophysiol 1996;100:436-42
Brecl J, Strand M, Zider I, Teckavcic- Pompe M. Pattern ERG and VEP maturation in school children. Clin Neurophysiol 2002;113:1764-70