THYROID HORMON LEVELS IN PATIENTS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Anahtar Kelimeler:

-

THYROID HORMON LEVELS IN PATIENTS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Aim; The severity of airway obstruction in chronic obstructive pulmonary diseases (COPD) is associated with impairment of thyroid gland function. Methods; We evaluated thyroid abnormalities in patients with COPD and relationship between pulmonary function tests, arterial blood gases and thyroid functions. Results; There was no significant difference in mean levels of TSH, FT3 and FT4 between COPD and control group. Serum level of TSH was lower than normal limits in 20 of 62 patients with COPD. Serum level of FT3 was higher than normal limits in 2 of 20 patients with lower TSH level. In control group, TSH was lower than normal limits in 2 patients, but FT3 was normal in these patients. There was significant difference according to percentage of cases with TSH less than minimum values and FT3 higher than maximum values between COPD and control group. Conclusion; we have demonstrated that both clinic and subclinic hyperthyroidism were higher in patients with COPD exacerbations than cases without COPD

Keywords:

COPD, thyroid hormones, pulmonary function tests arterial blood gases,

PDF

___

De Groot LJ. The nonthyroidal illness syndrome. J Clin Endocrinol Metab 1999;84:151-64
Chopra IJ. Euthyroid sick syndrome: is it a misnomer? J Clin Endocrinol Metab 1997;82:329-34
Opasich C, Pacini F, Ambrosino N et al. Sick euthyroid syndrome in patients with moderate-to-severe chronic heart failure. Eur Heart J 1996;17:1860-6
Schols AMWJ, Slangen J, Volovics L, Wouters EFM. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:1791-7
World Health Organization: World Health Report. Geneva, World Health Organization, 2000
Gow SM, Seth J, Beckett GJ, Douglas G. Thyroid function and endocrine abnormalities in elderly patients with severe chronic obstructive lung disease. Thorax 1987;42:520-5
Pino-Garcia JM, Garcia-Rio F, Diez JJ et al. Regulation of breathing in hyperthroidism: relationship to hormonal and metabolic changes. Eur Respir J 1998;12:400-7
Global Strategy fort the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/ WHO Workshop Rep. National Heart, Lung, and Blood Institute, Publ No 2701, 2001, p7
Dimopoulou I, Ilias I, Mastorakos G, Mantzos E, Roussos C, Koutras DA. Effects of Severity of Chronic obstructive pulmonary disease on thyroid function. Metabolism 2001;50(12):1397-1401
Semple Pd’A, Watson WS, Beastall GH et al. Diet absorbtion, and hormone studies in relation to body weight in obstructive airways disease. Thorax 1979; 34:783788
Gow SM, Seth J, Beckett GJ et al. Thyroid function and endocrine abnormalities in elderly patients with severe chronic obstructive lung disease. Thorax 1987;42: 520-25
Okutan O, Kartaloglu Z, Onde ME, Bozkanat E, Kunter E. Pulmonary function tests and thyroid hormone concentrations in patients with chronic obstructive pulmonary disease. Med Princ Pract 2004;13:126-8
Banks WA, Cooper JA. Hypoxia and hypercarbia of chronic lung disease: Minimal effects on anterior pituitary function. South Med J 1990;83:290-3
Opasich C, Pacini F, Ambrosino N et al. Sick euthyroid syndrome in patients with moderate-to-severe chronic heart failure. Eur Heart J 1996;17:1860-6