The prevalence of ankylosing spondylitis in the eastern black sea region of Turkey

Amaç: Bu çalışmanın amacı Türkiye’de Doğu Karadeniz Bölgesinde Ankilozan Spondilit (AS) prevalansını araştırmak idi. Metod: Çalışma Karadeniz Teknik Üniversitesi Fizik Tedavi ve Rehabilitasyon Anabilim dalı tarafından yürütüldü. Çalışma Doğu Karadeniz Bölgesinde 2000 yılı nüfus sayımına göre 459,021 kişilik popülasyona sahip kent merkezlerinde gerçekleştirildi. Örneklem metodu ile 20 yaşın üzerinde 4031 kişi 2025 ( %50.7 ) erkek ve 2006 (% 49.3) kadın çalışmaya dahil edildi. Hastalarda AS tanısı koymak için Modifiye New York (1987) kriterlerine uygun anket formları kullanıldı. Anket formları ve değerlendirmeler 2 araştırma görevlisi ve eğitim verilmiş 8 tıp fakültesi öğrencisi tarafından yapıldı. Şüpheli olgular kliniğimize davet edildi. Bulgular: Kliniğe davet edilen şüpheli 55 AS vakasından 41 kliniğimize başvurdu. Ayrıntılı fizik muayene, laboratuar ve röntgen bulguları sonrası, 10 hastaya AS tanısı konuldu. Hastaların 9’u erkek 1’i kadın idi. Hastaların ortalama yaşı 40.5 ± 8.4 yıl idi. AS prevalansı % 0.25 ( 95% CI: 0.09 -0.40) olarak tespit edildi. Cinsiyete dağılımına göre prevalans değerleri erkeklerde % 0.44 (95 % CI: 0.15–0.73) kadınlarda %0.05 (95 % CI: 0.0–0.15) idi. Sonuç: Çalışmamızın, ülkemizdeki AS prevalansını değerlendirmede, bölgesel niteliği bulunmaktadır. AS prevalansı % 0.25 olarak bulundu. Çalışmadaki AS hastaları arasında erkek yoğunluğu tespit edildi.

Türkiye’de Doğu Karadeniz Bölgesinde ankilozan spondilit (AS) prevalansı

Aim: The aim of this study was to estimate the prevalence of ankylosing spondylitis (AS) in the Eastern Black Sea region of Turkey. Method: The study was conducted by The Department of Physical Medicine and Rehabilitation, Karadeniz Technical University Medical Faculty, in the urban area in the Eastern Black Sea region of Turkey, which has a population of 459,021 (according to the 2000 national census). A total of 4031 subjects over 20 years-old were enrolled, using the sampling method; 2025 (50.7 %) men and 2006 (49.3 %) women were included in the study. A survey consistent with Modified New York Criteria 1987 was used to diagnose AS in patients. The survey was applied and evaluated by two physical medicine residents and 8 trained medical students. Suspected cases were invited to our clinic. Result: Forty one out of fifty patients suspected with AS attended our out- patient clinic. Following physical examination, laboratory tests and radiological investigations of those individuals with suspected AS, 10 ones were diagnosed as AS. 9 of 10 patients were male and 1 patient was female. Patients’ mean age was 40.5 ± 8.4 years. The prevalence was estimated to be 0.25 % (95% CI: 0.09 %-0.40 %). It was 0.44 % in men (95 % CI: 0.15-0.73) and 0.05 % in women (95 % CI: 0.0-0.15) according to gender distribution. Conclusion: The study had value of regional features for evaluating for epidemiology of AS in Turkey. The prevalence of AS was found to be as 0.25 %. A male predominance was noted among AS patients in the study.

___

  • 1. Gran JT, Husby G: Ankylosing spondylitis: Prevalence and demography. In: Klippell JH, Dieppe PA. Rheumatology, Mosby, Barcelona, 1998, 6-15: 1-6.
  • 2. Zink A, Braun J, Listing J, Wollenhaupt J. Disability and handicap in rheumatoid arthritis and ankylosing spodylitis- results from the German rheumatological database. German Collaborative Arthritis Centers. J Rheumatol 2000;27:613-22.
  • 3. Van der Linden SM, Valkenburg HA, de Jongh BM, et al. The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 1984;27:241-9.
  • 4. Gömör B, Gyodi E, Bakos L. Distribution of HLA and ankylosing spondylitis in the Hungarian population. J Rheumatol 1977;3:33-5.
  • 5. Onen F, Akar S, Birlik M, et al. Prevalence of ankylosing spondylitis and related spondyloarthritides in an urban area of Izmir, Turkey. J Rheumatol 2008;35(2):305-9.
  • 6. Yenal O, Umsan ON, Yassa K, et al. Epidemiology of rheumatic syndromes in Turkey, Incidence of rheumatic sacroiliitis in men of 20-22 years. J Rheumatol 1977;36:294-98.
  • 7. Vaughan JP, Morrow RH. Manual of Epidemiology for District Health Management. WHO Geneva, 1989. From English to Turkish: Bertan M, Enunlu T. Bölge Sağlık Yönetiminde Epidemiyoloji El Kitabı. Hacettepe Universitesi Tıp Fakültesi Halk Sağlığı Anabilim Dalı Yayın No: 90/51. Ankara, Turkey, 1990: 181-2.
  • 8. Calin A, Porta J, Fries JF, et al. Clinical history as a screening test for ankylosing spondylitis. JAMA 1977; 237:2613-14
  • 9. Van der Linden SM, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: A proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361-8
  • 10. Gotton JB, Robinson HS, Trueman GE. Ankylosing spondylitis in a Canadian Indian population. Ann Rheum Dis 1966;25:525-7.
  • 11. Trontzas P, Andrianakos A, Miyakis S, et al. Seronegative spondyloarthropathies in Greece: a population-based study of prevalence, clinical pattern, and management. The ESORDIG study. Clin Rheumatol 2005;24(6):583-9.
  • 12. De Angelis R, Salaffi F, Grassi W. Prevalence of spondyloarthropathies in an Italian population sample: a regional community-based study Scand J Rheumatol 2007;36:14- 21.
  • 13. Gran JT, Husby G, Ordvik M. Prevalence of ankylosing spondylitis in males and females in a young middle-aged population in Tromso, Northern Norway. Ann Rheum Dis 1985;44:359-67.
  • 14. Boyer GS, Lanier AP, Templin DW. Prevalence rates of spondyloarthropathies in Alaskan Eskimos. J Rheumatol 1994; 21: 12.
  • 15. Alexeeva L, Krylov M, Vturin V, et al. Prevalence of spondyloarthropathies and HLA-B27 in the native population of Chukotka, Russia. J Rheumatol 1994;21(12):2298-300.
  • 16. Saraux A, Guillemin F, Guggenbuhl P, et al. Prevalence of spondyloarthropathies in France: 2001. Ann Rheum Dis 2005;64:1431-5.
  • 17. Carbone LD, Cooper C, Michet CJ, et al. Ankylosing spondylitis in Rochester, Minnesota 1935-1989. Is the epidemiology changing? Arthritis Rheum 1992;35:1476-82.
  • 18. Sieper J, Rudwaleit M, Khan MA, et al. Concepts and epidemiology of spondyloarthritis.Best Pract Res Clin Rheumatol 2006;20:401-17.
European Journal of General Medicine-Cover
  • Başlangıç: 2015
  • Yayıncı: Sağlık Bilimleri Araştırmaları Derneği
Sayıdaki Diğer Makaleler

Transforming growth factor beta-1 in human colorectal cancer patients

İsmail HASIRCI, Mine ADAŞ, Ahu KEMİK SARBAY, Özgür KEMİK, Sevim PURİSA, Sefa TÜZÜN, Ahmet Cumhur DÜLGER

Evaluation of serum lipid profile in Turkish patients with chronic hepatitis C

Nurzen SEZGİN, Murat GÜLŞEN, Tolga YAKAR, Hakan SAKALLI, Mustafa GÜÇLÜ

Protective effects of rutin and naringin on gentamycin induced testicular oxidative stress

Raju B. AKONDI, Annapurna AKULA, Siva Reddy CHALLA

Diagnostic accuracy of 0.2 tesla open MR imaging unit in detecting meniscal tears: Correlation with arthroscopy

Mustafa KOPLAY, Ali Sami KIVRAK, Elif AKSAKALLI, Seda ÖZBEK, Serdar TOKER

Role of aerobic exercise training in changing exercise tolerance and quality of life in Alzheimer's disease

Shehab Mahmoud ABD EL-KADER

Neutropenic enterocolitis in a child with acute myelogenous leukemia

Serhat AVCU, Baran Serdar KIZILYILDIZ, Sinan AKBAYRAM, Gökmen TAŞKIN, Şahabettin SARI, Ahmet Faik ÖNER

The relationship between HLA antigens and blood groups

Tülin CORA, Mehmet ERİKOĞLU, Murat BÜYÜKDOĞAN

Addison’s disease due to bilateral adrenal infarction in a patient with myelodysplastic syndrome

Helen LOCKETT, Clive WOOD HAMILTON, Bijay VAIDYA

A new and simple silicone intubation method for dacryocystorhinostomy

Meral YILDIZ, Ali KARATAŞ, Berna AKOVA, Bülent YAZICI

Anticarcinogenic activity of allylmercaptocaptopril against aflatoxin-B1 induced liver carcinoma in rats

V. CHITRA, Shrinivas s SHARMA, Lakshmi KS, I. Aparna LAKSHMI, M. PARHM