Ekrem DOĞAN, Yasemin SOYORAL, Hayriye SAYARLIOĞLU, Reha ERKOÇ, Ahmet Faik ÖNER

Lymphocyte subtype and immunglobulins levels in hcv positive hemodialysis pateints

Epidemiyolojik çalışmalar kronik hemodiyaliz (HD) hastalarında bakteriyel ve viral enfeksiyonların mortalite ve morbiditede kardiyovasküler hastalıklardan sonra ikinci sırada yer aldığını göstermiştir. Kronik hepatit C virus enfeksiyonu bazı HD merkezler- inde çok yaygındır. Çalışmamızda, HCV?li HD hastalarında lenfosit subtiplerini ve immunoglobulin seviyelerini araştırdık. 55 HD teadvisi alan son dönem böbrek yetmezlikli hasta ve 21 sağlıklı gönüllü çalışmamıza aldık. Hasta grubuna ort yaş 46.5±16.1(18-77) olan 34 kadın ve 21 erkek dahil edildi. IgG, IgM, IgA serum konsantrasyonları ve CD4, CD8, CD19, CD16-56 lenfosit sayıları ölçüldü. Kt/V değerleri DOQI klavuzuna göre hesaplandı. Lenfosit ve lenfosit subgrup sayıları HD hastalarında kontrol grubuna göre anlamlı olarak düşük bulundu. IgG ve IgM değerleri HCV?li HD hastalarında HCV negatif HD hastalarına göre anlamlı olarak daha yüksekti. CD4/CD8 oranı açısında gruplar arasında fark yoktu. HCV negatif ve pozitif HD hastalarının lenfosit subtipleri sayıları arasında fark yoktu. HCV pozitif HD hastalarının IgG ve IgM seviyeleri HCV negatif HD hastalarından daha yüksekti. Yüksek Ig düzeyleri ALT seviyeleri ile ilgili olabilir.

Hcv pozitif hemodiyaliz hastalarında lenfosit subtipleri ve immunglobulin düzeyleri. Hcv, hemodiyaliz, Lenfosit ve immunglobulinler

Epidemiological studies indicate that in chronic HD patients, bacterial and viral infection rank second place in mortality and mor- bidity, behind cardiovascular disease. Chronic hepatitis C virus (HCV) is very prevalent in some Hemodialysis (HD) centers. We have investigated lymphocyte subtype count and immunoglobulin levels in hemodialyzed patient with HCV. We studied 55 patients with end stage renal disease (ESRD) on chronic HD and 21 healty subjects. Patients group included 34 female and 21 male with mean age 46.5±16.1(18-77) years. Serum concentrations of IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. Lymphocyte and lymphocyte subgroups values of HD patients were significant lower than healty persons. IgG, IgM and ALT levels of HCV positive HD patients compared with significant higher than HCV negative HD patients. CD4/CD8 ratios within groups were no differences. Lymphocyte subtype count of between HCV positive and HCV negative HD patients was no differences. IgG and IgM levels of HCV positive HD patients were higher than HCV negative HD patients. High Ig levels were also associated with ALT levels

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