MANDİBULADA MULTİPL MYELOMA İKİ OLGU SUNUMU

Multipl myeloma MM , erişkin çağın en sıkgörülen kemik tümörlerindendir. MM genellikle,kafatası, klavikula, vertebra, pelvis gibi yassıkemikleri tutar. Bu makalede mandibula posterior bölgeyitutan iki MM olgusu sunulmaktadır. İlk olgumuz57 yaşında alt çene sol tarafta ağrılı yumuşak dokukitlesi ile başvuran erkek hasta idi. İkinci olgumuzise 46 yaşında herhangi bir klinik şikayeti olmaks›z›n başvuran erkek hastayd›. Histopatolojik değerlendirmelerinde, plazma hücre infiltrasyonu ve immunohistokimyasal olarak kappa hafif zincir monoklonalitesi gözlenmiştir. MM 'da oral bulgular›n ortaya ç›kmas›, hastan›n ileri dönemde olduğuna işaret eder. Bu nedenle multipl myelomada olgular›n›n dikkatli değerlendirilmesi ve multidisipliner yaklaş›m gereklidir

Anahtar Kelimeler:

multipl myeloma, plazmahücreli tümör

Multiple Myeloma of the Mandible Report of two cases

Multiple myeloma MM is the most commonencountered malignant neoplasm of bone in adults.MM is generally seen in flat bones of skeleton suchas the skull, clavicle, vertebrae, and pelvis. In this article two cases of MM involved in themandible are presented. Our first case was a 57year- old man with a painful soft tissue mass atthe left side of his mandible. The second case was a46 year- old man without any clinical symptoms.The histopathologic evaluation revealed a plasmacell infiltration showing kappa light chainmonoclonality in the immunohistochemicalexamination. In both cases, the presence of oralfindings in the MM, suggest a terminal stage ofthe disease. Therefore, great attention must bepaid to the examination of such individuals andmultidisciplinary approach to the disease must beaccomplished

Keywords:

multiple myeloma, plasma cellneoplasm,

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