The purpose of these case reports is the follow-up of root development and lesions in the apical with different regenerative protocols applied to teeth with vital or vital open apex. In the first case, double antibiotic paste was used for 3 weeks to ensure disinfection, and in the second case, triple antibiotic paste was used. Regeneration treatment was applied with apical bleeding method in the first case and with PRF in the second case. After the blood clots were formed, closure was provided with MTA Plus. It was observed that the lesion area healed completely at the end of 1 year and gave a positive response to the pulp test with electricity. In the second case, it was observed that the radiolucent area in the apical region was greatly improved during the 6th month follow-up, and a positive response was obtained for the pulp test with electricity and the cold test.