Profesyonel Voleybolcularda Katekol-O-Metiltransferaz (COMT) rs4680 Polimorfizminin Belirlenmesi
Katekol-O-Metil Transferaz (COMT) katekolamin nörotransmitterlerin (dopamin, epinefrin,
Determination of Catechol-O-Methyltransferase (Comt) rs4680 Polymorphism in Professional Volleyball Players
Catechol-O-Methyl Transferase (COMT) is involved in the inactivation of catecholamine neurotransmitters(dopamine, epinephrine, norepinephrine). The discovered functional polymorphisms in the COMTgene are known to cause changes in COMT enzyme activity. In our study, the Val (108/158) Met rs4680polymorphism of the COMT gene was examined in professional volleyball players and it was aimed todetermine the genotype and allele distributions of COMT rs4680 polymorphism in volleyball players.In this context, 21 professional volleyball athletes participated in our study. The genotyping study wascompleted with real-time polymerase chain reaction (RT-PCR) after swab DNA isolation. According tothe results of our study, AA, AG and GG genotype distributions in our athletes; In 6 of our athletes (29%),7 of our athletes (33%) had GA and 8 of our athletes (38%) had AA genotype. When we look at the allelnumbers of our volleyball players, G Allele was 19 (45%) and A Allele 23 (55%). AA genotype in ourcohort was higher than other genotypes, compared to A allele G allele. According to our findings, volleyballathletes’ low activity AA genotype has been proved to be a biomarker for predisposition to volleyball sport.Our study is the first research to examine the effect of COMT rs4680 polymorphism on volleyball players.
Keywords:
COMT, Volleyball, Genetics, Sport, SNP,
___
- Abe, D., Doi, H., Asai, T., Kimura, M., Wada, T., Takahashi, Y. & Shinohara, K. (2017). Association between COMT Val158Met polymorphism and competition results of competitive swimmers. Journal of Sports Sciences, 36(4), 1–5.
- Butovskaya, P. R., & Vasilyev, M. L. B. (2013). Molecular-Genetic Polymorphisms of Dopamine, Serotonin and Androgenic Systems as Molecular Markers of Success in Judo Wrestling Sportsmen. Journal of Bioanalysis & Biomedicine, s3(01), 1–6.
- Breda, V.K., Collins, M., Stein, D. J., & Rauch, L. (2015). The COMT val158met polymorphism in ultraendurance athletes. Physiology & Behavior, 151, 279–283.
- Corak, A., Kapıcı, S., Sercan, C., Akkoç, O. & Ulucan, K. (2017). A pilot study for determination of anxiety related SLC6A4 promoter “S” and “L” alleles in healthy Turkish athletes. Cellular and Molecular Biology, 63(5), 29-31.
- Eken, B.F., Akpınaroğlu, C., Arslan, K.S., Sercan, C. & Ulucan, K. (2018). Genlerin sporda psikolojik faktörlerle ilişkisi, The Journal of Neurobehavioral Sciences, 5(1), 56-61.
- Grossman, M. H., Emanuel, B. S., & Budarf, M. L. (1992). Chromosomal mapping of the human catechol-Omethyltransferase gene to 22q11.1-q11.2. Genomics, 12(4), 822–825.
- Knöpfli, B., Calvert, R., Bar-Or, O., Villiger, B., & Von Duvillard, S. P. (2001). Competition performance and basal nocturnal catecholamine excretion in cross-country skiers. Medicine and science in sports and exercise, 33(7), 1228–1232.
- Mc Fie, S., Abrahams, S., Patricios, J., Suter, J., Posthumus, M., & September, A. V. (2018). The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players. Journal of Sports Sciences, 36(8), 920–933.
- Tenhunen, J., Salminen, M., Lundström, K., Kiviluoto, T., Savolainen, R., & Ulmanen, I. (1994). Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. European journal of biochemistry, 223(3), 1049–1059.
- Ulucan, K., Yalcin, S., Akbas, B., Uyumaz, F., & Konuk, M. (2014). Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball players. The Journal of Neurobehavioral Sciences, 1(2), 37.
- Ulucan, K., Topal, E.S., Aksulu, B.K., Yaman, B., Çiftçi, İ.C., & Türker Bıyıklı. (2015). Atletik Performans, Genetik ve Gen Dopingi. İKSST Derg, 7(2),58-62.
- ISSN: 2636-8269
- Yayın Aralığı: Yılda 2 Sayı
- Başlangıç: 2015
- Yayıncı: Marmara Üniversitesi
Sayıdaki Diğer Makaleler
Sporcular Tarafından Algılanan Antrenör Davranışlarının Bazı Değişkenlere Göre İncelenmesi
Profesyonel Voleybolcularda Katekol-O-Metiltransferaz (COMT) rs4680 Polimorfizminin Belirlenmesi
Seçil TUNALI, Selin YİĞİT, Canan SERCAN, Tolga POLAT, Rıdvan EKMEKÇİ, Korkut ULUCAN
Farklılıkla Öğrenme Antrenmanlarının Basketbol Oyuncuları Üzerindeki Etkisi