Orhan DELİCE, Murat DAŞ, Gülhan KURTOĞLU ÇELİK, Havva ŞAHİN KAVAKLI, Salim NEŞELİOĞLU, Semra IŞIKOĞLU HATIL
Acil Serviste Karbonmonoksit Zehirlenmesi Tanısı Alan Hastalarda Plazma Total Tiyol Seviyelerinin Değerlendirilmesi
Anahtar Kelimeler:
karbon monoksit zehirlenmesi, , oksidatif stres, total tiyol seviyeleri
Evaluation of Plasma Total Thiol Levels in Patients with Carbon Monoxide Poisoning in the Emergency Department
Objective: The study aimed to measure the levels of total thiol, an antioxidant parameter, in patients who presented to the emergency department (ED) with carbon monoxide (CO) poisoning under normobaric oxygen therapy (NBOT), evaluate the time-dependent changes in total thiol levels within the first 6 hours, and examine the course of antioxidants in CO poisoning.
Materials and Method: The study population consisted of 85 patients diagnosed with CO poisoning in the ED and 50 volunteers. Total thiol level was measured in the study group at the admission (T0), first (T1) and sixth hour (T6). Carboxyhemoglobin levels, cardiac markers, electrocardiography, and routinely requested tests were investigated in patients with poisoning. The total thiol level was measured in the volunteer group.
Results: There was a significant decrease in total thiol mean levels between T0 and T1 (p <0.01), a significant increase between T1 and T6 (p <0.01), and a significant increase between T0 and T6 (p <0.01). No significant difference was found for T6 total thiol mean level between the patient and the control group (p >0.05).
Conclusion: The significant decrease in the total thiol mean value from T0 to T1 may suggest that the oxidative stress continues within the first hour, and the initiation of the significant increase in the total thiol level within T1 may indicate that the oxidative stress decreased with treatment. Six hours of NBOT protocol is sufficient for acute CO poisoning in patients not requiring HBOT.
Keywords:
carbon monoxide poisoning, oxidative stress, total thiol level,
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- Yayın Aralığı: Yılda 3 Sayı
- Başlangıç: 2019
- Yayıncı: Acil Tıp Uzmanları Derneği
Sayıdaki Diğer Makaleler
Orhan DELİCE, Murat DAŞ, Gülhan KURTOĞLU ÇELİK, Havva ŞAHİN KAVAKLI, Salim NEŞELİOĞLU, Semra IŞIKOĞLU HATIL
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