The objectives of this study were to determine the physicochemical properties and antioxidant composition of four mango varieties (Tommy Atkins, Apple, Keitt, and Kent) grown in Ethiopia and to compare their composition to previously reported results on mangoes grown in other parts of the world. The Keitt variety had the highest fruit weight, fruit length, fruit diameter, and juice volume content. The pH, TSS, TA, and TSS/TA and proximate composition (moisture, ash, fat, fiber, and protein) showed significant differences among the varieties at p ≤ 0.05. Minerals such as Na, Mg, K, Ca, Fe and Zn were also evaluated and potassium had the highest concentration among the minerals with the grand mean of 267.44 mg/100 g. Varieties also differed in antioxidant content such as total carotenoids and vitamin C with values ranging from 0.6 to 4.8 µg/g and 14.2 to 36.4 mg/100 g, respectively. Apple, Kent and Keitt mango varieties are good sources of vitamin C. The four mango varieties had similar physicochemical properties and antioxidant content compared to mangoes grown in other countries.