Muhammed Semih GEDİK, Muhammed ÇİFTÇİOĞLU

EVALUATION AND DIAGNOSTIC EFFECTIVENESS OF HEMOGRAM, BIOCHEMISTRY AND INFLAMMATORY MARKERS (IMMATURE GRANULOCYTE, PROCALCITONIN, CRP, NLR, PLR) IN PATIENTS WITH SEPSIS

Aim This study aimed to reveal the contributions of hemogram values and inflammatory markers involved in the pathology and progression of sepsis, and other biochemical markers such as C-reactive protein, procalcitonin, delta neutrophil index (immature granulocyte), calcium and zinc levels to the diagnosis of sepsis, and the relationship of these markers with each other. Material and Method This is a descriptive epidemiological study. Patients aged 18 years and over who were diagnosed with sepsis in the Emergency Department and Internal Diseases Service of Kahramanmaraş Sütçü Imam University Medical Faculty Hospital between 11.10.2022 - 11.06.2023 were prospectively included in the study. Results In our study, it was found that leukocyte, neutrophil, neutrophil lymphocyte ratio, platelet lymphocyte ratio, immature granulocyte, copper, phosphorus, blood glucose, C-reactive protein and procalcitonin values were high in patients with sepsis. The levels of albumin, calcium, zinc and lymphocyte were found to be low. Conclusion The use of biomarkers in sepsis has increasingly become important in diagnosing, following treatment, determining prognosis and predicting mortality. The biomarkers examined in this study are believed to be a reference for future studies on their use in the diagnosis, treatment and prognosis follow-up of sepsis.

Keywords:

Sepsis, Hemogram, Biochemistry, Immature granulocyte Copper, Zinc,

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Meltem Malkoç, Birgül Vanizor Kural. Presepsin: Sepsis Tespiti İçin Umut Verici Yeni Bir Biyobelirteç. CBU-SBED, 2021, 8(3): 553-557. DOI: 10.34087/cbusbed.887818
Cem Ece, İlkin Çankayali, Canan Bor, Kubilay Demirağ, Mehmet Uyar, Ali Reşat Moral. Yoğun bakım hastalarında serum CRP düzeylerinin sepsis değerlendirmesindeki yeri. Ege Tıp Dergisi / Ege Journal of Medicine 2020; 59 (3): 174-180. https://doi.org/10.19161/etd.790461
Sönmezer MÇ, Tülek N. Bakteriyel İnfeksiyonlarda ve Sepsiste Biyobelirteçler. Klimik Dergisi 2015; 28(3): 96-102. DOI: 10.5152/kd.2015.20
Seok Y, Choi JR, Kim J, Kim YK, Lee J, Song J, et al. Delta neutrophil index: a promising diagnostic and prognostic marker forsepsis. Shock. 2012 Mar;37(3):242-6. doi: 10.1097/SHK.0b013e3182454acf
Nilgün Eroğlu, Gülseren Şahin, Ferda Özbay Hoşnut, Gürses Şahin. Çölyak Hastalığı Diyet Uyumunda Yeni Bir Belirteç: Delta Nötrofil İndeks? Kocatepe Medical Journal 22:294-299/ Temmuz 2021. https://doi.org/10.18229/kocatepetip.864099
Yalan Liu, Yannan Chai, Zhihui Rong, Yan Chen. Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis. Ann Nutr Metab. 2020;76(3):193-200. doi: 10.1159/000508685
Emine Esin Yalınbaş, Hüseyin Bilgin. Geç Neonatal Sepsis Tanısında Trombosit Parametreleri Ve Nötrofil Lenfosit Oranlarının Değerlendirilmesi. Kocatepe Tıp Dergisi. 21:104-109/2020 Özel Sayısı (1). https://doi.org/10.18229/kocatepetip.557896
Alkan Baylan F., Orak F., Doğaner A., Güler S., İnal Ş., Sağer H. İmmatür Granülositler; Gerçek Bakteriyemiyi Kontaminasyondan Ayırabilir Mi?. JHS. 2022; 31(2): 164-168. https://doi.org/10.34108/eujhs.860436
Arcagok BC, Karabulut B. Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early onset Neonatal Sepsis. Mediterr J Hematol Infect Dis. 2019 Sep 1;11(1):e2019055. doi: 10.4084/MJHID.2019.055
Can E, Hamilcikan Ş, Can C. The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. J Pediatr Hematol Oncol. 2018 May;40(4):e229-e232. doi: 10.1097/MPH.0000000000001059
Kim JW, Park JH, Kim DJ, Choi WH, Cheong JC, Kim JY. The delta neutrophil index is a prognostic factor for postoperative mortality in patients with sepsis caused by peritonitis. PLoS One. 2017 Aug 1;12(8):e0182325. doi: 10.1371/journal.pone.0182325
Ha SO, Park SH, Park SH, Park JS, Huh JW, Lim CM, et al. Fraction of immature granulocytes reflects severity but not mortality in sepsis. Scand J Clin Lab Invest. 2015 Jan;75(1):36-43. doi: 10.3109/00365513.2014.965736
Omran A, Maaroof A, Saleh MH, Abdelwahab A. Salivary C-reactive protein,mean platelet volüme and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. J Pediatr (RioJ).2018;94(1):82-87. DOI: 10.1016/j.jped.2017.03.006
Fatih Aygün. Çocuk yoğun bakımda magnezyum düzeyi prognoz ve enfeksiyon ile ilişkili midir? Online Türk Sağlık Bilimleri Dergisi 2019, Cilt 4, Sayı 1, 37-46. https://doi.org/10.26453/otjhs.442454
İdris Akkaş. Sepsis hastalarında eser elementlerin araştırılması/Investigation of trace elements in sepsis patients. (Tıpta Uzmanlık Tezi). Düzce Üniversitesi / Tıp Fakültesi / Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı, 2018, 99s.
Levent Döşemeci. Sepsis Ve Kan Şekeri Kontrolü. ANKEM Derg. 2006;20(Ek2):67-69.