Türkiye’de 2005-2008 Yılları Arasında İzole Edilen Kuş Gribi Viruslarının Genetik Analizi

Türkiye’de Yüksek Patojen Kuş Gribi H5N1 enfeksiyonu ilk olarak 07 Ekim 2005 tarihinde rapor edildi. Hastalık Balıkesir ili Manyas ilçesi Kızıksa Köyünde bir hindi çiftliğinde tek bir vaka olarak şekillendi. Bu vakayı takiben 2005, 2006, 2007 ve 2008 yıllarında Türkiye’nin değişik bölgelerinde yeni vakalar şekillendi. Bu çalışmada 2005 ve 2008 yılları arasında Türkiye’de izole edilen Yüksek Patojen Kuş Gribi H5N1 viruslarının karakterizasyonları yapılmıştır. Bu izolatların Haemagglutinin geninin kısmi filogenetik analizi genetik olarak Asya’da bulunanlar ile yakın ilişkide olduğunu göstermektedir.

Anahtar Kelimeler:

Etlik Veterinerlik Mikrobiyoloji Dergisi, Türkiye, 2005-2008, İzolasyon, Kuş Gribi, Virus, Genetik, Hikmet ÜN, 2008

Genetic Analysis of Highly Pathogenic Avian Influenza A (HPAI) H5N1 Viruses Isolated From Turkey Between 2005 and 2008

An outbreak of Highly Pathogenic Avian Influenza A (HPAI) H5N1 infection was first reported on 07 October 2005 in Turkey. There was a single outbreak in free range turkeys in the west side of the country on the Aegean coast in Kızıksa Village of Manyas District of Balıkesir Province. Following this outbreak, there were new outbreaks in different regions of Turkey respectively in December 2005, 2006, 2007 and 2008. This study provides a characterization of HPAI H5N1 viruses isolated from Turkey that caused between 2005 and 2008. A phylogenetic analysis of the hemagglutinin gene showed that the Turkish HPAI H5N1 isolates were genetically closely related to the Asian lineage.

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