Filiz DEMİR, Suna KALENDER, Yavuz ULUSOY, Fatma Gökçe UZUN

Malathion’un ratların ince bağırsak dokusu üzerine etkisi ve vitamin C ve E’nin koruyucu rolü

Organofosfatlı bir pestisit olan malathion pestleri kontrol etmek için tarımda ve ev uygulamalarında sıklıkla kullanılan bir insektisittir. Bu çalışmada 300–320 g ağırlığındaki erkek Wistar ratlara vitamin C (200 mg/kg) + vitamin E (200 mg/kg), malathion (27 mg/kg) ve vitamin C (200 mg/kg) + vitamin E (200 mg/kg) + malathion (27 mg/kg) 4 hafta süreyle oral gavaj yoluyla verilmiştir. Uygulamadan 4 hafta sonra ratların ince bağırsaklarındaki histopatolojik değişiklikler ışık mikroskobu altında kontrol grubu ile karşılaştırmalı olarak incelenmiştir. Malathion uygulandıktan 4 hafta sonra ratların ince bağırsaklarında nekroz, ödem ve hiperemi gibi histopatolojik değişiklikler gözlenirken vitamin C + vitamin E + malathion uygulanan grupta nekroz ve mononüklear hücre infiltrasyonu gözlenmiştir. Sonuç olarak düşük doz malathion’un ratların ince bağırsaklarında histopatolojik değişikliklere neden olduğu tespit edilmiştir. Vitamin C ve vitamin E’nin malathion’un ince bağırsakta neden olduğu histopatolojik değişiklikleri önlemediği gözlenmiştir.

Anahtar Kelimeler:

Histopatoloji, ince bağırsak, malathion, vitamin C, vitamin E., Fatma Gökçe UZUN, Yavuz ULUSOY, Filiz DEMİR, Suna KALENDER, 2010, Etlik Veteriner Mikrobiyoloji Dergisi

Effects of malathion in small intestine tissue of rats and protective role of vitamin C and E

Malathion is an organophosphate pesticide that is widely used in agricultural and household applications to control pests. In this study, sexually mature male Wistar rats (weighing 300–320 g) were given malathion (27 mg/kg) and/or vitamin C (200 mg/kg) + vitamin E (200 mg/kg) daily via gavage for 4 weeks. At the end of fourth week, histopathological changes in small intestine were investigated using light microscope comparatively with control group. Necrosis, edema and hyperemia were observed in the small intestine tissues of malathion treated group. It was observed that there were necrosis and mononuclear cell infiltration in the small intestine of vitamin C + vitamin E + malathion treated group. As a result, lower doses of malathion caused histopathological changes in the rat small intestine. It was determined that vitamin C and vitamin E have not prevented the histopathological changes caused by malathion in small intestine tissues.

Keywords:

Histopathology, malathion, small intestine, vitamin C, vitamin E.,

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