Avianize Kelev Kuduz Aşısı ile Semple Tipi Kuduz Aşısının Köpeklerde Meydana Getirdiği Muafiyetin Serolajik Olarak Tesbiti

Altı aylıktan büyük 20 köpek üzerinde avianize Kelev ve inaktiv Semple aşıları mukayeseli olarak denendi. 10 köpeğe adele içi 2,5 ml Kelev aşısı, 10 köpeğe deri altı yoluyla 10 gün ara ile iki defada 10'ar ml Semple aşısı verildi. Bu köpeklerde aşılamadan evvel ve · aşılandıktan sonra 1 ci. 3 üncü, 6 ncı ve 12 nci aylar kan a'lınarak serum nötralizasyon testi yapıldı. Aşılamadan önce alınan serumlardan sadece 1 numaralı köpekte antikor tesbit edildi. Her iki gruptan beşer adet köpek aşılamanın altıncı ayında birer doz aşı ile revaksine edildi. Serum Nötralizasyon testinin sonuçları (Cetvel: I ve II) de görülmektedir. Kelev aşısında, nötralizan antikor aşılamanın birinci ayında iki, üçüncü ayında beş, altıncı ayında dokuz köpekte tesbit edildi. Revaksineden sonra beş köpeğin antikor titrelerinde biraz yükselme, onikinci ay alınan serumlarda ise 16 numaralı köpek müstesna diğer dokuz köpekte antikor mevcut olduğu görüldü. Semple aşısında, aşılamanın birinci ayında üç, üçüncü ayında üç, altıncı ayında ise dört köpekte antikor tesbit edilmiş, altıncı ayda epruve edilen beş köpekten bilhassa üç adedinü1 kanındaki antikor titresi çok yükselmiş, onikinci ay serumlarında sadece revaksine edilenlerden dört adedinde antikor tesbit edilebilmiş, diğerlerinde kayda değer birşey bulunamamıştır. Bu deneme göstermiştir ki Kelev aşısının bir dozu köpeklerde, bir sene devam eden antikor tevlit etmektedir.

Anahtar Kelimeler:

Avianize Kelev Kuduz Aşısı, Kuduz, Avianize Kelev, Semple, Köpek

Comparative Studies on Vaccination of dogs With Avianized Kelev Virus and unactivated Semple Vaccine

Avianized Kelev and inactivated Semple rables Vaccines comparativly tested on 20 dogs, older than six months: In this experiment 10 dogs were vaccinated with Kelev vaccine 2.5 ml intramuscularly Another 10 dogs were inoculated twice, at ten days interval with a dose of 10 ml inactiveted Semple vaccine. A serum- neutralization test was carried out on these dogs before and at 1 st, 3 rd, 6 the and 12 th months after vaccination. Only the Nr. 1 dog serum had prevaccination antibodies. Revaccination carried out on 5 dogs from each group at the end of sixth month of the first vaccaination. (Table: I and II) showing the results of serum neutralization test. The neutralizing antibodies of Kelev vaccine established in 2 dogs in the first month, in S dogs in the third month, and in 9 dogs at the end of sixth months of the vaccination. The revaccinated 5 dogs showed some rising titers of antibodies. After twelve months, all the sera contained a certain amount of antibidies excpt Nr. 16. We obtained the following results with the Semple vaccine test: Antibodies demonstrated in 3 dogs after one month, in 3 dogs after three months and in 4 dogs after six months of vaccination. Three out of 5 revaccinated animals gave the high antibody titers. With- this test only 4 revaccinated dogs gave antibodies at the end of twelve months. It was understood that one dose of Kelev vaccine produce antibodies for one year.

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Etlik Veteriner Mikrobiyoloji Dergisi-Cover

ISSN: 1016-3573
Yayın Aralığı: Yılda 2 Sayı
Başlangıç: 1960
Yayıncı: Veteriner Kontrol Merkez Araştırma Enstitüsü Müdürlüğü

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