Breast Tumor Detection and Classification Based on Microwave Imaging

Breast Tumor Detection and Classification Based on Microwave Imaging

Limitations caused by traditional breast cancer detection and screening techniques have encouraged researchers to investigate alternative solutions. This study examines the use of a microwave-based approach for tumor detection in breast tissue and related tumor type classification using matched-filtering. Radar-like confocal microwave imaging (CMI) method constructs the foundation of such tumor detection approach. In particular, a microwave pulse is first transmitted, then back-scattered pulses are collected. All major reflective sites in the breast tissue are detected by repeating this procedure on a microwave pulse transmission-reception grid, aligning captured signals in-time to focus on a particular region in the breast tissue and superimposing such time-shifted signals to improve signal-to-clutter level. In the observed signals, clutter is originated by the heterogeneity of the breast tissue while signal is originated by a tumor site as a function of its water content. All calculations, in the study, were performed computationally in terms of a 3D Finite-Difference Time-Domain (FDTD) simulation models. For the antenna system, two cross-polarized resistively loaded bow-ties antennas were used in the computational model, and the tumor site was modeled using five different size and morphologies. Matched-filtering, on the other hand, was performed matching such obtained observations with that of a homogenous breast tissue, namely clutter-free model. Performance of the proposed approach was tested for two different antenna array resolutions, and it was observed that this parameter is important for successful detection and classification of a tumor-site in a realistic heterogenous breast tissue model.

___

  • American Cancer Society. Cancer Facts & Figures 2021; American Cancer Society: Atlanta, GA, USA, 2021. Available online: https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2021.html (accessed on 21 April 2022)
  • S. Kwon, S. Lee, “Recent advances in microwave imaging for breast cancer detection”, Int. J. Biomed. Imaging. 2016, 5054912
  • S.G. Orel, M.D. Schnall, “MR imaging of the breast for the detection, diagnosis, and staging of breast cancer”, Radiology 2001, 220, 13–30
  • M.A. Aldhaeebi, T.S. Almoneef, H. Attia, O.M. Ramahi, “Near-Field Microwave Loop Array Sensor for Breast Tumor Detection”, IEEE Sens. J. 2019, 19, 11867-11872
  • B. Bocquet, J. Van de Velde, A. Mamouni, Y. Leroy, G. Giaux, J. Delannoy, D. Delvalee, “Microwave radiometric imaging at 3 GHz for the exploration of breast tumours”, IEEE Trans. Microw. Theory Tech. 1990, 38, 791–793
  • S. Mouty, B. Bocquet, R. Ringot, N. Rocourt, P. Devos, “Microwave radiometric imaging (MWI) for the characterisation of breast tumours”, Eur. Phys. J. Appl. Phys. 2000, 10, 73–78
  • P.M. Meaney, M.W. Fanning, D. Li, S.P. Poplack, K.D. Paulsen, “A clinical prototype for active microwave imaging of the breast”, IEEE Trans. Microw. Theory Tech. 2000, 48, 1841–1853
  • M. Ambrosanio, P. Kosmas, V. Pascazio, “A Multithreshold Iterative DBIM-Based Algorithm for the Imaging of Heterogeneous Breast Tissues”, IEEE Trans. Biomed. Eng. 2018, 66, 509–520
  • M. Maffongelli, S. Poretti, A. Salvadè, R. Monleone, C. Pagnamenta, A. Fedeli, M. Pastorino, A. Randazzo, “Design and experimental test of a microwave system for quantitative biomedical imaging”, Proceedings of the 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Rome, Italy, 11–13 June 2018; pp. 1–6
  • S.P. Rana, M. Dey, G. Tiberi, L. Sani, A. Vispa, G. Raspa, M. Duranti, M. Ghavami, S. Dudley, “Machine Learning Approaches for Automated Lesion Detection in Microwave Breast Imaging”, Clinical Data. Sci. Rep. 2019, 9, 10510
  • O.M. Bucci, G. Bellizzi, A. Borgia, S. Costanzo, L. Crocco, G. Di Massa, R. Scapaticci, “Experimental framework for magnetic nanoparticles enhanced breast cancer microwave imaging”, IEEE Access 2017, 5, 16332–16340
  • S. C. Hagness, A. Taflove, J. E. Bridges, “Two-Dimensional FDTD Analysis of a pulsed Microwave Confocal System for Breast Cancer Detection: Fixed-Focus and Antenna-Array Sensors,” in IEEE Trans. On Biomed. Eng., vol. 45, no. 12, pp. 1470-1479, Dec. 1998
  • S. C. Hagness, A. Taflove, J. E. Bridges, “Three-Dimensional FDTD Analysis of a pulsed Microwave Confocal System for Breast Cancer Detection: Design of an Antenna-Array Element,” in IEEE Trans. On Antennas Propagat., vol. 47, no. 5, pp. 783-791, May 1999
  • X. Li, S. C. Hagness, “A Confocal Microwave Imaging Algorithm for Breast Cancer Detection,” in IEEE Microwave and Wireless Letters, vol. 11, no. 3, pp. 130-132, Mar. 2001
  • S. Coarsi, A. Massa, M. Pastorino, “Numerical Assessments Concerning a Focused Microwave Diagnostic Method for Medical Applications,” in IEEE Trans. On Microwave Theory and Tech., vol. 48, no. 11, pp. 1815-1830, Nov. 2000
  • K. R. Foster, and H. P. Schwan, “Dielectric properties of tissues and biological materials: A critical review,” Critical Reviews Biomed. Eng., vol. 17, no. 1, pp. 25-102, 1989
  • K. R. Foster, and J. L. Schepps, “Dielectric properties of tumor and normal tissues at radio through microwave frequencies,” Journal Microwave Power, vol. 16, no. 2, pp. 107-119, 1981
  • E. C. Fear, M. A. Stuchly, “Microwave Detection of Breast Cancer,” in IEEE Trans. On Microwave Theory and Tech., vol.48, no. 11, pp. 1854-1863, Nov. 2000
  • J. Shea, P. Kosmas, B. Van Veen, S. Hagness, “Contrast-enhanced microwave imaging of breast tumours: A computational study using 3D realistic numerical phantoms”, Inverse Probl. 2010, 26, 074009
  • D. Byrne, M. O’Halloran, M. Glavin, E. Jones, “Data independent radar beamforming algorithms for breast cancer detection”, Prog. Electromagn. Res. 2010, 107, 331–348
  • D. Byrne, M. Sarafianou, I.J. Craddock, “Compound radar approach for breast imaging”, IEEE Trans. Biomed. Eng. 2017, 64, 40–51
  • T. Yin, F.H. Ali, C.C. Reyes-Aldasoro, “A robust and artifact resistant algorithm of ultra-wideband imaging system for breast cancer detection”, IEEE Trans. Biomed. Eng. 2015, 62, 1514–1525
  • S. Kubota, X. Xiao, N. Sasaki, Y. Kayaba, K. Kimoto, W. Moriyama, T. Kozaki, M. Hanada, T. Kikkawa, “Confocal imaging using ultra wideband antenna array on Si substrates for breast cancer detection”, Jpn. J. Appl. Phys. 2010, 49, 097001
  • I. Ünal, B. Türetken, C. Canbay, “Spherical Conformal Bow-Tie Antenna for Ultra-Wide Band Microwave Imaging of Breast Cancer Tumour”, Appl. Comput. Electromagn. Soc. J. 2014, 29
  • G.N. Bindu, S.J. Abraham, A. Lonappan, V. Thomas, C.K. Aanandan, K. Mathew, “Active microwave imaging for breast cancer detection”, Prog. Electromagn. Res. 2006, 58, 149–169
  • E. C. Fear, X. Li, S. C. Hagness, M. A. Stuchly, “Confocal Microwave Imaging for Breast Cancer Detection: Localization of Tumors in Three Dimensions,” IEEE Trans. On Biomed. Eng., vol. 49, no. 8, pp. 812-822, Aug. 2002