Gül İLBAY, Aymen BALIKÇI

Wistar Sıçanlarda Erken Dönem Deneyimlerinin Duyusal Motor Yanıtlar Üzerine Etkileri

Amaç: Merkezi sinir sisteminin gelişiminde erken dönem deneyimleri önem taşır. Çalışmamızda yaşamın kritik erken gelişim döneminde verilen taktil uyarı ile motor görev deneyimlerinin duyusal motor gelişim üzerine etkilerinin incelenmesi amaçlanmıştır. Gereç ve yöntem: Çalışmamızda doğum sonrası 3. gün ile 21. gün arasında iki ayrı gruptaki sıçan yavrularına taktil uyarı ya da basamaklı köprüde yürüme şeklinde motor görev verilmiştir. Diğer bir gruba da anneden ayırma işlemi uygulanmıştır. Kontrol grubu olarak ise anneleri ile birlikte kalan yavrular kullanılmıştır. Tüm gruplarda yavrular 22. güne ulaştıklarında değerlendirmeye alınmışlardır. Değerlendirmede basamaklı köprü adımlama puanlama skalasının duyusal motor yanıtlar bölümü kullanılmıştır. Sonuçlar: Doğum sonrası 22. günde kontrol grubundaki ve taktil uyarı verilen gruptaki hayvanlar erişkin değerlerine yakın yüksek skor puanları göstermişlerdir. Motor görev verilen ya da anneden ayrı kalan gruplarda ise düşük skor puanları saptanmıştır. Gruplar arasındaki farklar istatistiksel olarak da anlamlı bulunmuştur (p

The Effects of Early Life Experiences on Sensorimotor Responses in Wistar Rats

Purpose: Early life experiences are very important for development of central nervous system. The aim of our study is to investigate the effects of tactile stimulation and motor task experiences at critical period of development. Materials and method: The pups in two different group are given tactile stimulation or walking on rung bridge task apparatus between post natal day 3 and 21. We aplied maternal seperation to another group. The pups who were with their mother in their cage are used as control group. All pups evaluated at day 22. Sensorimotor responses category of rung bridge stepping task scale was used for evaluation. Results: Both control group and tactile stimulation group animals demonstrated high scores which is close to mature points at post natal day 22. Low scores determined at motor task group or maternal separation group. The differences between groups were statistically significant (p

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Antonini, A., & Stryker, M.P. (1996). Plasticity of geniculocortical afferents following brief or prolonged monocular occlusion in the cat. J Comp Neurol, 369(1), 64-82.
Baldini S., Restani, L., Baroncelli, L., Coltelli, M., Franco, R., Cenni, M. C., & et.al. (2013). Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1. J Neurosci, 33(28), 11715-23.
Bardi, M., Kaufman, C., Franssen C., Hyer, M. M., Rzucidlo, A., Brown, M., & et.al. (2016). Paper or Plastic? Exploring the effects of natural enrichment on behavioural and neuroendocrine responses in long-evans rats. J Neuroendocrin, 28(5). doi: 10.1111/jne.12383.
Baumans, V. (2005). Environmental enrichment for laboratory rodents and rabbits: requirements of rodents, rabbits, and research. ILAR J,46(2),162-70.
Bekinschtein,. P., Oomen, C.A., Saksida,. L.M., & Bussey, T.J. (2011). Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable? Semin Cell Dev Biol, 536-42.
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990). Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci, 87(14), 5568-72.
Boufleur, N., Antoniazzi, C. T., Pase, C. S., Benvegnú, D.M., Dias, V.T., Segat, H. J., & et. al. (2012). Neonatal handling prevents anxiety-like symptoms in rats exposed to chronic mild stress: behavioral and oxidative parameters. Stress, 16(3), 321-30.
Cancedda, L., Putignano, E., Sale, A., Viegi, A., Berardi, N., & Maffei, L. (2004). Acceleration of visual system development by environmental enrichment. J Neurosci, 19;24(20), 4840-8.
Chapillon,. P., Patin,. V., Roy,. V., Vincent, A., & Caston, J. (2002). Effects of pre- and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: a review. Dev Psychobiol, 41(4),373-87.
Field, T., & Diego, M. (2008) Vagal activity, early growth and emotional development. Infant Behav Dev, 31(3),361-73.
Field,. T.M., Schanberg, S.M., Scafidi, F., Bauer, C.R., VegaLahr. N., Garcia, R., & et.al. (1986). Tactile/kinesthetic. stimulation effects on preterm neonates. Pediatrics, 77(5), 654-8.
Huntley, G. W. (1997). Differential effects of abnormal tactile experience on shaping representation patterns in developing and adult motor cortex. J Neurosci, 17(23),9220-32.
Gibb,. R. L., Gonzalez,. C. L., Wegenast,. W., & Kolb, B. E. (2010). Tactile stimulation promotes motor recovery following cortical injury in adult rats. Behav Brain Res, 214(1), 102-7.
Guzzetta,. A., Baldini,. S,. Bancale. A., Baroncelli, L., Ciucci, F., Ghirri, P. & et.al. (2009). Massage accelerates brain development and the maturation of visual function. J Neurosci, 29(18), 6042-51.
Imanaka,. A., Morinobu,. S., Toki,. S., Yamamoto, S., Matsuki, A., Kozuru, T., & et.al. (2008). Neonatal tactile stimulation reverses the effect of neonatal isolation on open-field and anxiety-like behavior, and pain sensitivity in male and female adult Sprague-Dawley rats. Behav Brain Res, 186(1), 91-7.
Kobilo, T., Liu, Q., Gandhi, K., Mughal, M., Shaham, Y., & van Praag, H. (2011). Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn Mem, 18(9), 605-609.
Kolb,. B., & Gibb, R. (2010). Tactile stimulation after frontal or parietal cortical injury in infant rats facilitates functional recovery and produces synaptic changes in adjacent cortex. Behav Brain Res,. 214(1), 115-20.
Kuhn,. C. M., & Schanberg,. S. M.(1998). Responses to maternal separation: mechanisms and mediators. Int J Dev Neurosci, 16(3-4), 261-70.
Lakhani, B., Borich, M.R., Jackson, J.N.,. Wadden, K.P.,. Peters, S., Villamayor A. & et.al. (2016). Motor skill acquisition promotes human brain myelin plasticity. Neural Plast, doi: 10.1155/2016/7526135.
Landi, S., Sale A, Berardi, N., Viegi, A., Maffei, L., & Cenni, M. C.(2007). Retinal functional development is sensitive to environmental enrichment: a role for BDNF. FASEB J, 21(1), 130-9.
Metz,. G. A., & Whishaw, I. Q. (2002). Drug-induced rotation intensity in unilateral dopamine- depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance. Neuroscience, 111(2), 325-36.
Procianoy,. R. S., Mendes,. E. W., & Silveira,. R. C.(2010). Massage therapy improves neurodevelopment outcome at two years corrected age for very low birth weight infants. Early Hum Dev, 86(1), 7-11.
Ramakrishnan,. K. B., Voges,. K., De. Propris,. L., De Zeeuw, C. I., & D'Angelo, E. (2016). Tactile stimulation evokes long-lasting potentiation of purkinje cell discharge ın vivo." Front Cell Neurosci, 10,36. doi: 10.3389/ fncel.2016.00036.
Richards,. S., Mychasiuk,. R., Kolb,. B., & Gibb, R. (2012). Tactile stimulation during development alters behaviour and neuroanatomical organization of normal rats. Behav Brain Res, 231(1), 86-91.
Roggeri,. L., Rivieccio,. B., Rossi,. P., & D'Angelo, E. (2008). Tactile stimulation evokes long-term synaptic plasticity in the granular layer of cerebellum. J Neurosci, 28(25), 6354-9.
Shriner,. A. M., Drever, F. R., & Metz,. G.A. (2009). The development of skilled walking in the rat. Behav Brain Res, 205(2), 426-35.
Valeri, B. O., Holsti, L., & Linhares, M.B.M. (2015). Neonatal pain and developmental outcomes in children born preterm: A systematic review. Clin J Pain, 31(4), 355- 362.
van Praag,. H., Kempermann,. G., & Gage,. F. H. (2000). Neural consequences of environmental enrichment. Nat Rev Neurosci, 1(3), 191-8.
Vivar, C., Potter, M.C., & van Praag, H. (2013). All about running: Synaptic plasticity, growth factors and adult hippocampal neurogenesis. Curr Top Behav Neurosci,15,189-210.
Wei, B., Tai, F., Liu, X., Ma, L., Yang, X., Jia, R., & et.al. (2013). Neonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles. Physiol Behav, 112-113, 14- 22.
Wertheimer, G. S., Girardi, C. E., de Oliveira, A. S., Monteiro Longo, B., & Suchecki, D. (2016). Maternal deprivation alters growth, food intake, and neuropeptide. Y. in the. hypothalamus of adolescent maleand female rats. Dev Psychobiol. doi: 10.1002/dev.21440.
Westwood, J. A., Darcy, P. K., & Kershaw, M. H.(2013). Environmental enrichment does not impact on tumor growth in mice. F1000Res, 2,140.