Nonsteroidal Antiinflamatuvar İlaçların Kedi ve Köpeklerde Etkili ve Güvenli Kullanımı

Nonsteroidal antiinflamatuvar ilaçların (NSAİİ) ağrı kesici, ateş düşürücü, yangı önleyici etkilerinin yanında antiromatizmaletkilerinin de olması nedeniyle veteriner hekimlikte kullanımı oldukça yaygındır. NSAİİ’ların kimyasal yapılarıbirbirinden farklı olmasına rağmen, prostoglandinlerin üretimine aracılık eden siklooksijenaz enzimini (COX) inhibe edereketkinlik gösterirler. COX enzimi COX-1, COX-2 ve COX-3 olmak üzere üçe ayrılmaktadır. NSAİİ’lar COX-1 ve COX-2’yifarklı derecelerde inhibe ederek yangıya yol açan prostaglandinlerin üretimini azaltırlar. NSAİİ’ların kullanılmasına bağlıolarak şiddetli organ disfonksiyonları ile sonuçlanabilen bozukluklar oluşabilir. NSAİİ’ların istenmeyen yan etkilerindenkedi ve köpeklerin diğer hayvan türlerinden daha fazla etkilendiği belirtilmektedir. Bu kapsamda klinik açıdan önemlibazı yangı önleyici ilaçların kedi ve köpeklerde etkili ve güvenli kullanımı değerlendirilecektir.

Anahtar Kelimeler:

Kedi, köpek, nonsteroidal antiinflamatuvar ilaç, siklooksijenaz

The Effective and Safe use of Nonsteroidal Antiinflammatory Drugs in Dogs and Cats

Non-Steroidal Anti-Inflammatory Drugs (NSAID) are commonly used in veterinary medicine because oftheir analgesic, antipyretic, anti-inflammatory effects in addition to their anti-rheumatic effects. Despite differences inchemical structures of the NSAID, these compounds share the effect of inhibiting the production of prostoglandins bytargeting the cyclooxygenase (COX) pathway. Three primary forms of COX have been identified as COX-1, COX-2 andCOX-3. The NSAIDs reduce the production of prostoglandins causing inflamation by inhibitting the COX-1 and COX-2 enzymes in different levels. Depending on the use of NSAIDs, severe organ dysfunctions may occur. The clinicaladverse effects associated with NSAID administration are observed more often in dogs and cats than other animals. Inthis review, some clinically important anti-inflammatory drugs will be evaluated in terms of their effective and safe usein cats and dogs.

Keywords:

Cat, dog, nonsteroidal antiinflammatory drug, cyclooxygenase,

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