Gülay YÜZBAŞIOĞLU ÖZTÜRK, Hazal ÖZTÜRK GÜRGEN, Belgi NASİBOĞLU, Funda YILDIRIM1

Metastazik Oral Melanomlu Bir Köpekte Sitopatolojik Bulgular

Oral malign melanomlar, köpeklerin ağız tümörleri arasında en sık rastlanılan tümörlerdir. Hızlı büyüme gösterirler, bölge lenf yumrusu ve uzak metastaz oranı yüksektir ve kötü prognoza sahiptirler. Olguda ağız boşluğunda evre 4 malign melanom teşhis edilen 13 yaşlı, erkek, Golden Retriever ırkı köpekte klinik, sitolojik, makroskobik ve mikrosko-bik bulgular değerlendirildi ve sonuçlar güncel literatür bilgisi ile tartışıldı. Oral tümörlerin tanısında sitolojik teşhisin, hastalığın erken tanısında önemli yere sahip olabileceği ve hastanın yaşam süresi ve kalitesi üzerine olumlu etkisi ola-bileceği düşünüldü.

Anahtar Kelimeler:

Köpek, malign melanom, oral, prognoz, sitoloji

Cytopathological Findings in a Dog With Metastatic Oral Melanoma

Oral malignant melanomas are the most common canine oral tumors. They have rapid growth rate, and potential to metastasis to lymph node and distant tissues in a short time. Therefore malign melanomas have a poor prognosis. In the case, clinical, cytological, macroscopic and microscopic findings were evaluated in a 13-year-old, male, Golden Retriever dog malignant melanoma in stage 4 in the oral cavity, and the findings were discussed in light of current literature knowledge. It was thought that cytological diagnosis in the diagnosis of oral tumors may be impor-tant in the early diagnosis of these tumors and may have a positive effect on the life span and life quality of the patient.

Keywords:

Cytology, dog, malign melanoma, oral, prognosis,

PDF

___

Bergman PJ. Canine oral melanoma. Clin Tech Small Anim Pract 2007; 22: 55-60.
Bonfanti U, Bertazzolo W, Gracis M, Roccabianca P, Romanelli G, Palermo G, Zini E. Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: A pro-spective study on 114 cases. Vet J 2015; 205(2): 322-7.
Brodey RS. A clinical and pathologic study of 130 neoplasms of the mouth and pharynx in the dog. Am J Vet Res 1960; 21: 787-812.
Esplin DG. Survival of dogs following surgical exci-sion of histologically well-differentiated melanocytic neoplasms of the mucous membranes of the lips and oral cavity. Vet Pathol 2008; 45: 889-96.
Felizzola CR, Stopiglia AJ, Araujo NS. Oral tumors in dogs. Clinical aspects, exfoliative cytology and his-topathology. Ciência Rural 1999; 29(3): 499-506.
Gishleni G, Roccobianca P, Ceruti R, Stefanell D, Bertazzolo W, Bonfanti U, Caniatti M. Correlation between fine-needle aspiration cytology and histo-pathology in the evaluation of cutaneous and sub-cutaneous masses from dogs and cats. Vet Clin Pathol 2006; 35(1): 24-30.
Hahn KA, DeNicola DB, Richardson RC, Hahn EA. Canine oral malignant melanoma: prognostic utility of an alternative staging system. J Small Anim Pract 1994; 35(5): 251-6.
Millanta F, Fratini F, Corazza M, Castagnaro M, Zap-pulli V, Poli A. Proliferation activity in oral and cuta-neous canine melanocytic tumours: correlation with histological parameters, location, and clinical be-haviour. Res Vet Sci 2002; 73: 45-51.
Munday JS, Löhr CV, Kiupel M. Tumors of the ali-mentary tract. Meuten DJ. ed. In: Neoplasms in Domestic Animals. Fifth Edition. Iowa: Iowa State University Press 2017; pp. 499-601.
Ramos-Vara JA, Beissenherz ME, Miller MA, John-son GC, Pace LW, Fard A, Kottler SJ. Retrospec-tive study of 338 canine oral melanomas with clini-cal, histologic, and immunohistochemical review of 129 cases. Vet Pathol 2000; 37: 597-608.
Schultheiss PC. Histologic features and clinical out-comes of melanomas of lip, haired skin, and nail bed locations of dogs. J Vet Diagn Invest 2006; 18: 422-5.
Smedley RC, Spangler WL, Esplin DG, Kitchell BE, Bergman PJ, Ho HY, Bergin IL, Kiupel M. Prognos-tic markers for canine melanocytic neoplasms: a comparative review of the literature and goals for future investigation. Vet Pathol 2011; 48: 54-72.
Smith SH, Goldschmidt MH, McManus PM. A com-parative review of melanocytic neoplasms. Vet Pathol 2002; 39: 651-78.
Vos JH, Van der Gaag I. Canine and feline oral-pharyngeal tumours. Zentralbl Veterinarmed A 1987; 34:420-7.
Weiss E, Frese K. Histological classification and no-menclature of tumours of the skin. Bull World Health Organ 1974; 50:79-100.
Williams LE, Packer RA. Association between lymph node size and metastasis in dogs with oral malig-nant melanoma: 100 cases (1987-2001). J Am Vet Med Assoc 2003; 222 (9): 1234-6.