Kezban ŞAHNA, Seçil ABAY, K. Semih GÜMÜŞSOY, Murat KİBAR

İnfeksiyöz bovine keratokonjunktivitisin tedavisinde flortfenikol ve sefuroksim sodyum uygulaması

Bu çalışmada, süt sığırlarında infeksiyöz bovine keratokonjunktivitisin klinik, bakteriyolojik ve virolojik yönden incelenmesi ile tedavide florfenikol ve sefuroksim sodyumun etkinliklerinin saptanması amaçlandı. Klinik olarak incelenen 450 hayvandan 27 (% 6)'sinde blefarospazm, epifora, korneal opasite ve konjunktivitis saptandı. İnfekte hayvanların gözlerinden alınan svap örneklerinden Moraxella bovis, Escherichia coli, Proteus spp. ve Staphylococcus aureus izole edildi. İnfekte sığırlardan alınan kan serumlarının mikronötralizasyon testi ile incelenmesi sonucu 3 (% 11.1) sığırda Bovine Herpesvirus-1 (BHV-1) antikoru tespit edildi. Florfenikol ve sefuroksim sodyumun etkinliğini saptamak amacıyla hayvanlar biri kontrol olmak üzere üç eşit gruba ayrıldı. Deneme gruplarındaki hayvanlara 48 saat ara ile 3 defa subkonjunktival yolla florfenikol ve sefuroksim sodyum uygulandı. Kültürel yoklama sonuçlarına göre florfenikol ve sefuroksim sodyumun tedavideki etkinliği sırasıyla % 78 ve % 67 olarak saptandı. Sonuç olarak, keratokonjunktivitisli sığırlardan infeksiyonun primer etkeni olarak M. bovis izole edildi. İnfeksiyöz bovine keratokonjunktivitisin tedavisinde subkonjunktival yolla florfenikol uygulamasının sefuroksim sodyuma oranla daha etkili olduğu saptandı.

The use of florfenicol and cefuroxime sodium in the treatment of infectious bovine keratoconjuntivitis

This study was carried out to evaluate the clinical, bacteriological and virological aspects of the infectious bovine keratoconjunctivitis and to determine the therapeutic effects of florfenicol and cefuroxime sodium in dairy cattle. Blephoarospasm, epiphora, corneal opasite and conjunctivitis were observed in 27 of 450 (6 %) clinically examined-animals. Moraxella bovis, Escherichia coli, Proteus spp. and Staphylococcus aureus were isolated from the conjunctival swabs collected from infected animals. Bovine Herpesvirus-1 (BHV-1) was determined in the serum of 3 (11.1 %) infected cattle by microneutralization test. Infected animals were divided into three equal groups as control and treatment to determine the efficacy of the florfenicol and cefuroxime sodium. Florfenicol and cefuroxime sodium were given subconjuctivally 3 times with 48 hour intervals to the animals in experiment groups. Therapeutic effectiveness of florfenicol and cefuroxime sodium was found as 78 % and 67 % by cultural examination respectively. In conclusion, M. bovis was isolated as the primary causative agent of keratoconjunctivitis infection in dairy cattle. It was determined that subconjuctival florfenicol administration was more effective than cefuroxime sodium in the keratoconjunctivitis treatment.

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