Gül Aslıhan ÇAKIR AKAY, Esin YALÇINKAYA AYAYDIN

Evaluation Of Autologous Serum Skin Testing Results In Patients With Seasonal Allergic Rhinitis

Objective: Autologous serum skin testing is a practical test for basophil histamine release which is used in the diagnosis of chronic autoimmune urticaria. Although the exact autoimmune pathogenesis of allergic diseases of the upper respiratory tract remains a matter of debate, recent studies have reported positive results for autologous serum skin test in both allergic and non-allergic rhinitis, asthma sufferers, and even in healthy controls. In this study, we aimed to evaluate positive results from autologous serum testing in patients with allergic rhinitis and to compare the results with those from healthy controls. Methods The study included 76 seasonal allergic rhinitis patients and 51 healthy volunteers aged between 18-65 years who underwent autologous serum skin testing. A chi-square test was used for comparisons between the two groups. Results Autologous serum testing proved positive in 29 of the patients with allergic rhinitis and in 10 of the healthy controls. The number of positive results from autologous serum testing was found to be significantly higher in patients with allergic rhinitis than in the control group. Conclusion Autologous serum skin testing may have benefits beyond merely detecting chronic urticaria. In the present study, the number of allergic rhinitis patients who demonstrated autologous serum skin testing positivity was significantly higher than the healthy controls. The findings of the present study may contribute further studies that investigate common pathological mechanisms of allergic rhinitis and chronic idiopathic urticaria patients who show positivity to autologous serum skin testing.

PDF

___

1- Kakli HA, RileyTD. Allergic rhinitis. Prim Care 2016;43:465-75.

2- Skoner DP. Allergic rhinitis: Definition, epidemiology, pathopysiology, detection and diagnosis. J Allergy Clin Immunol 2001;108:2-8.

3- Khan DA. Allergic rhinitis and asthma: Epidemiology and common pathophysiology. Allergy Asthma Proc 2014;35:357-61.

4- Kumaran MS, Mangal S, Narang T, Parsad D. Autologous serum and plasma skin test in chronic spontaneous urticaria: A reappraisal. Indian Dermatol Online J 2017;8:94-9.

5- Grattan CEH. Autoimmune urticaria. Immunol Allergy Clin North Am 2004;24:163-81.

6- Asero R, Lorini M, Chong SU, Zuberbier T, Tedeschi A. Assesment of histamin-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells. Clin Exp Allergy 2004;34:1111-4.

7- Mari A. Allergy-like asthma and rhinitis – a cross sectional survey of a respiratory cohort and a diagnostic approach using the autologous serum skin test. Int Arch Allergy Immunol 2004;133:29-39

8- Tedeschi A, Comi AL, Lorini M, Tosini C, Miadonna A. Autologous serum skin test reactivity in patients with non-allergic asthma. Clin Exp Allergy 2005;35:849-53.

9- Asero R, Tedeschi A, Lorini M. Autoreactivity is highly prevalent in patients with multiple intolerances to NSAIDs. Ann Allergy Asthma Immunol 2002;88:468-72.

10- Asero R, Tedeschi A, Lorini M, Caldironi G, Barocci F. Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. Int Arch Allergy Immunol 2003;131:195-200.

11- Guttman-Yassky E, Bergman R, Maor C, Mamorsky M, Pollack S, Shahar E.. The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals. J Eur Acad Dermatol Venereol 2007;21:35-9.

12- Sabroe RA, Fiebiger E, Francis DM, et al. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol 2002;110:492-9.

13- Toubi E, Kessel A, Avshovich N, et al. Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy 2004;59:869-73.

14- Zuberbier T, Henz BM, Fiebiger E, Maurer D, Stingl G. Anti-FcepsilonRIalpha autoantibody in different subtypes of urticaria. Allergy 2000;55:951- 4.

15- Horn MP, Gerster T, Ochensberger B et al. Human antiFcepsilonRI alpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur J Immunol 1999;29:1139-48.

16- Taşkapan O, Kutlu A, Karabudak O. Evaluation of autologous serum skin test results in patients with chronic urticaria, allergic/non-allergic asthma or rhinitis and healhy people. Clin Exp Dermatol 2008;33:754-8.

17- Marasoğlu Çelen O, Kutlubay Z, Aydemir EH. Usefulness of the autologous serum test for the diagnosis of chronic idiopathic urticaria. Ann Dermatol 2014;26:592-7.

18- Kurt E, Aktaş A, Aksu K, et al. Autologous serum skin test response in chronic spontaneous urticaria and respiratory disease and its relationship with serum interleukin-18 level. Arch Dermatol Res 2011;303:643-9.