Correlation of Clinical Factors and Loss of Taste and Smell in Patients with Coronavirus Disease 2019

Correlation of Clinical Factors and Loss of Taste and Smell in Patients with Coronavirus Disease 2019

Objective: The Covid-19 pandemic continues to threaten the whole world. Early diagnosis of patients is very important to prevent the spread of the virus. Sudden loss of taste and smell is a common early symptom in patients. Therefore, it is thought that revealing the pathogenesis of the symptom will help both in early diagnosis and in predicting the prognosis. Materials and Methods: The age, gender, predominant symptoms during Covid, length of stay at home/hospital, and smoking status of patients who had Covid and had loss of taste and smell between July 2020 and December 2020 were evaluated retrospectively. Results: Patients with loss of taste and smell were significantly younger than those who did not. The majority were female patients, non-smokers, and patients needing significantly less hospitalization and receiving treatment at home. Among the accompanying symptoms, GIS symptoms were also significantly more common in this group. Conclusion: Loss of taste and smell is an important symptom in Covid-19 infection. Revealing the demographic and clinical characteristics associated with this symptom is valuable in terms of early diagnosis of the disease, predicting the prognosis and reducing the contagiousness.

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  • 1. Guan WJ, Ni ZY, Hu Y, et al; China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382(18): 1708-1720. [Crossref]
  • 2. Zou X, Chen K, Zou J, Han, P, Hao, J, Han, Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019- nCoV infection. Front Med. 2020; 14 (2): 185-192. [Crossref]
  • 3. Cazzolla AP, Lovero R, Muzio LR, et al. Taste and smell disorders in COVID-19 patients: Role of interleukin 6. ACS Chem. Neurosci. 2020; 11: 2774-2781. [Crossref]
  • 4. Santacroce L, Charitos IA, and Del Prete R. COVID19 in Italy: An overview from the first case to date. Electron J. Gen Med. 2020; 17 (6): No. em235. [Crossref]
  • 5. Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study. Eur Arch Otorhinolaryngol. 2020. [Crossref]
  • 6. Yamagishi M, Fujiwara M, Nakamura H. Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology. 1994; 32(3): 113-118.
  • 7. American Academy of Otolaryngology-Head and Neck Surgery Foundation. ENT Health. Hyposmia and anosmia. Alexandria, VA: American Academy of Otolaryngology-Head and Neck Surgery Foundation; 2020. [INTERNET] https://www.enthealth.org/conditions/hyposmia-and-anosmia/. Accessed May 14, 2020.
  • 8. Beltran-Corbellini A, Chico-Garcıa JL, Martınez-Poles J, et al. Acute-onset smell and taste disorders in the context of COVID-19: A pilot multicentre polymerase chain reaction based case-control study. Eur J Neurol. 2020; 27(9): 1738-1741. [Crossref]
  • 9. Izquierdo-Dominguez A, Rojas-Lechuga MJ, Chiesa-Estomba C, et al. Smell and taste dysfunctions in COVID-19 are associated with younger age in ambulatory settings - A multicenter cross-sectional study. J Investig Allergol Clin Immunol. 2020; 30(5): 346-357. [Crossref]
  • 10. Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H, Murakami S. Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope. 2007; 117(2): 272-277. [Crossref]
  • 11. De Haro-Licer J, Roura-Moreno J, Vizitiu A, González-Fernández A, González-Ares JA. Long term serious olfactory loss in cold and/or flu. Acta Otorrinolaringol Esp. 2013; 64(5): 331-338. [Crossref]
  • 12. Passarelli PC, Lopez MA, Bonaviri GNM, Garcia-Godoy F, D’adonna A. Taste and smell as chemosensory dysfunctions in COVID-19 infection. Am J of Dentistry. 2020; 33 (3): 135-137.
  • 13. Borsetto D, Hopkins C, Philips V, Obholzer R, Tirelli G, Polesel J, Boscolo-Rizzo P. Self-reported alteration of sense of smell or taste in patients with COVID-19: A systematic review and meta-analysis on 3563 patients. Rhinology. 2020; 58 (5): 430-436. [Crossref]
  • 14. Boesveldt S, Postma EM, Boak D, et al. Anosmia-A Clinical Review. Chemical Senses. 2017; 42(7): 513-523. [Crossref]
  • 15. Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020; 12(1): 8. [Crossref]
  • 16. AU Noor, F Maqbool, ZA. Bhatti, AU Khan. Epidemiology of CoViD-19 pandemic: Recovery and mortality ratio around the globe. Pak J Med Sci. 2020; 36: 79-84. [Crossref]
  • 17. Kerr C, Hughes G, McKenna L, Bergin C. Prevalence of smell and taste dysfunction in a cohort of COVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland. Infection Prevention in Practice. 2020; 2(3): 100027. [Crossref]
  • 18. Somekh I, Hanna HYH, Heller E, Bibi H, Somekh E. Age-dependent sensory impaırment in COVID-19 infectıon and its correlation with ace2 expressıon. The Pediatric Infectious Disease Journal. 2020; 39(9): 270-272. [Crossref]
  • 19. Mercante G, Ferreli F, De Virgilio A, et al. Prevalence of taste and smell dysfunction in coronavirus disease 2019. JAMA Otolaryngol Head Neck Surg. 2020; 146(8): 723-728. [Crossref]
  • 20. Giacomelli A, Pezzati L, Conti F. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: A cross-sectional study. Clin Infect Dis. 2020. [Crossref]
  • 21. Reddy RK, Charles WN, Sklavounos A, Dutt A, Seed PT, Khajuria A. The effect of smoking on COVID-19 severity: A systematic review and meta-analysis. J Med Virol. 2021; 93(2): 1045-1056. [Crossref
  • 22. Al-Ani RM, Acharya D. Prevalence of anosmia and ageusia in patients with COVID-19 t a primary health center, Doha, Qatar. Indian J Otolaryngol Head Neck Surg. 2020. [Crossref]
  • 23. Nobel YR, Phipps M, Zucker J, Lebwohl B, Wang TC, Sobieszczyk MA, Freedberg DE. Gastrointestinal symptoms and coronavirus disease 2019: A case-control study from the United States. Gastroenterology. 2020 Jul; 159(1): 373-375.e2. [Crossref]
  • 24. Liou JM, Chen MJ, Hong TC, Wu MS. Alteration of taste or smell as a predictor of COVID-19. Gut. 2020; 70(4):806-807. [Crossref]
  • 25. Leung JM, Yang CX, Tam A. ACE-2 expression in the small airway epithelia of smokers and COPD patients: Implications for COVID-19. Eur Respir J. 2020; 14; 55(5): 2000688. [Crossref]
ENT Updates-Cover
  • ISSN: 2149-7109
  • Başlangıç: 2015
  • Yayıncı: Prof.Dr.Murat Demir
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